Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.55 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.55 |
| ▸ | TUBB | P07437 | 4/20 | 0.55 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.55 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.55 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.55 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.55 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.55 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.55 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.55 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.55 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.55 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.55 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.55 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.55 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13394635 | 0.91 | CYP3A4 (0.61) | CYP3A4CYP2C9CYP2C19TUBB4ATUBB | |
| SCHEMBL7607290 | 0.85 | TUBB4A (0.63) | CYP3A4CYP2C9CYP2C19TUBB4ATUBB | |
| SCHEMBL12337064 | 0.84 | TUBB4A (0.56) | CYP3A4CYP2C9CYP2C19TUBB4ATUBB | |
| SCHEMBL682464 | 0.79 | CYP3A4 (0.81) | CYP3A4CYP2C9CYP2C19TUBB4ATUBB | |
| SCHEMBL12145856 | 0.73 | CYP3A4 (0.82) | CYP3A4CYP2C9CYP2C19TUBB4ATUBB | |
| SCHEMBL10073426 | 0.72 | CYP3A4 (0.70) | CYP3A4CYP2C9CYP2C19TUBB4ATUBB | |
| SCHEMBL682243 | 0.72 | CYP3A4 (0.70) | CYP3A4CYP2C9CYP2C19TUBB4ATUBB | |
| Noscapine SCHEMBL10307295 | 0.71 | CYP3A4 (1.00) | CYP3A4CYP2C9CYP2C19TUBB4ATUBB | |
| Noscapine SCHEMBL14400084 | 0.71 | CYP3A4 (1.00) | CYP3A4CYP2C9CYP2C19TUBB4ATUBB | |
| Noscapine SCHEMBL2494164 | 0.71 | CYP3A4 (1.00) | CYP3A4CYP2C9CYP2C19TUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011109237-A2 | USES OF NOSCAPINE AND DERIVATIVES IN SUBJECTS DIAGNOSED WITH FAP | EMORY UNIVERSITY (US) | 2011-09-09 | — | — | WO | disclosed |