Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 2/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.46 |
| ▸ | AURKA | O14965 | 4/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 4/20 | 0.36 |
| ▸ | FLT3 | P36888 | 4/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12342108 | 0.94 | CSF1R (0.54) | CSF1RRPS6KB1AURKAPDPK1AURKB | |
| SCHEMBL12341431 | 0.90 | CSF1R (0.49) | CSF1RRPS6KB1AURKAPDPK1AURKB | |
| SCHEMBL12338612 | 0.85 | CSF1R (0.41) | CSF1RRPS6KB1KITCACNA1BCYP2C19 | |
| SCHEMBL1267328 | 0.85 | CSF1R (0.68) | CSF1RRPS6KB1AURKAPDPK1AURKB | |
| SCHEMBL12342106 | 0.83 | CSF1R (0.51) | CSF1RRPS6KB1AURKAPDPK1AURKB | |
| SCHEMBL12343934 | 0.83 | CSF1R (0.55) | CSF1RRPS6KB1AURKAAURKBKIT | |
| SCHEMBL14147163 | 0.80 | KDR (0.44) | CSF1RRPS6KB1AURKAPDPK1AURKB | |
| SCHEMBL12341435 | 0.80 | RPS6KB1 (0.42) | CSF1RRPS6KB1AURKAPDPK1AURKB | |
| SCHEMBL1267604 | 0.78 | CSF1R (0.71) | CSF1RRPS6KB1AURKAPDPK1AURKB | |
| SCHEMBL857418 | 0.77 | CSF1R (0.65) | CSF1RRPS6KB1PDPK1AURKBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268858-B2 | e.g. 5-(3-methoxybenzyloxy)-1H-pyrrolo[2,3-b]pyridine; protein kinases inhibitor; central nervous system disorders; Alzheimer's disease; Parkinson's disease; anticancer, antitumor agents; analgesics; cogestive heart failure; skin disorders; inflammatory bowel disorders; transplant rejection | PLEXXIKON INC. (US) | 2012-09-18 | — | — | US | disclosed |