Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 3/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 6/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 5/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12341431 | 0.93 | CSF1R (0.49) | CSF1RRPS6KB1CACNA1BCACNA1HKIT | |
| SCHEMBL12338611 | 0.90 | CSF1R (0.40) | CSF1RRPS6KB1KITLTA4HCYP2C19 | |
| SCHEMBL12342108 | 0.90 | CSF1R (0.54) | CSF1RRPS6KB1CACNA1BCACNA1HKIT | |
| SCHEMBL1267604 | 0.85 | CSF1R (0.71) | CSF1RRPS6KB1CACNA1BCACNA1HKIT | |
| SCHEMBL12341853 | 0.84 | CSF1R (0.54) | CSF1RRPS6KB1CACNA1BKITAURKA | |
| SCHEMBL12341433 | 0.83 | CSF1R (0.53) | CSF1RRPS6KB1CACNA1BKITAURKA | |
| SCHEMBL14147163 | 0.83 | KDR (0.44) | CSF1RRPS6KB1AURKAPDPK1AURKB | |
| SCHEMBL12342164 | 0.83 | CSF1R (0.52) | CSF1RRPS6KB1CACNA1BCACNA1HKIT | |
| SCHEMBL12338612 | 0.80 | CSF1R (0.41) | CSF1RRPS6KB1CACNA1BKITLTA4H | |
| SCHEMBL1267328 | 0.79 | CSF1R (0.68) | CSF1RRPS6KB1CACNA1BCACNA1HKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268858-B2 | e.g. 5-(3-methoxybenzyloxy)-1H-pyrrolo[2,3-b]pyridine; protein kinases inhibitor; central nervous system disorders; Alzheimer's disease; Parkinson's disease; anticancer, antitumor agents; analgesics; cogestive heart failure; skin disorders; inflammatory bowel disorders; transplant rejection | PLEXXIKON INC. (US) | 2012-09-18 | — | — | US | disclosed |
| US-20080188514-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC | 2008-08-07 | — | — | US | disclosed |
| WO-2008079909-A1 | PYRROLO [2,3-B] PYRIDINES AS KINASE MODULATORS | PLEXXIKON, INC. (US) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188514-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | MAP3K20, MAP3K13, MAP3K8 | CSF1R 2023/4885RPS6KB1 111/4885CACNA1B 3325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.