Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | FLT3 | P36888 | 4/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 10/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 3/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12341431 | 0.90 | CSF1R (0.49) | KDRFLT3AURKBAURKANTRK1 | |
| SCHEMBL12338611 | 0.85 | CSF1R (0.40) | CYP1A2RPS6KB1CSF1RCYP2C19 | |
| SCHEMBL1267483 | 0.85 | CYP3A4 (0.54) | KDRFLT3AURKBCYP1A2CNR1 | |
| SCHEMBL12342106 | 0.83 | CSF1R (0.51) | KDRFLT3AURKBAURKAPDPK1 | |
| SCHEMBL12342164 | 0.80 | CSF1R (0.52) | KDRFLT3AURKBAURKANTRK1 | |
| SCHEMBL14197523 | 0.76 | CYP2C19 (0.44) | KDRFLT3AURKBCYP1A2CNR1 | |
| SCHEMBL12338612 | 0.75 | CSF1R (0.41) | CYP1A2RPS6KB1CSF1RCYP3A4CYP2C19 | |
| SCHEMBL1267328 | 0.75 | CSF1R (0.68) | KDRFLT3AURKBCYP1A2AURKA | |
| SCHEMBL14147160 | 0.75 | CSF1R (0.42) | KDRFLT3AURKBCYP1A2CSF1R | |
| SCHEMBL1268047 | 0.74 | CSF1R (0.50) | KDRFLT3AURKBCYP1A2GPR55 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079909-A1 | PYRROLO [2,3-B] PYRIDINES AS KINASE MODULATORS | PLEXXIKON, INC. (US) | 2008-07-03 | — | — | WO | disclosed |