Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12277480 | 0.80 | PRNP (0.45) | HTTLMNASMN1; SMN2CCNCCDK8 | |
| SCHEMBL13917362 | 0.78 | HTT (0.45) | HTTLMNASMN1; SMN2CCNCCDK8 | |
| SCHEMBL18450619 | 0.74 | TNF (0.45) | HTTLMNASMN1; SMN2CCNCCDK8 | |
| SCHEMBL12277481 | 0.68 | HTT (0.41) | HTTLMNASMN1; SMN2CCNCCDK8 | |
| SCHEMBL6193855 | 0.68 | MMP13 (0.46) | MMP13 | |
| SCHEMBL15648567 | 0.67 | GABRA1 (0.44) | HTTLMNASMN1; SMN2GABRA1GABRG2 | |
| SCHEMBL12266572 | 0.66 | HTT (0.43) | HTTLMNASMN1; SMN2CCNCCDK8 | |
| SCHEMBL20392630 | 0.65 | SLC22A12 (0.48) | HTTLMNACCNCCDK8MAPT | |
| SCHEMBL30162599 | 0.65 | ADORA2A (0.43) | SMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL27757810 | 0.65 | ERN1 (0.43) | HTTLMNASMN1; SMN2BCL2BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2301544-B1 | Quinoline derivatives as intermediates to mycobacterial inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2012-09-19 | — | — | EP | disclosed |
| EP-2301544-A1 | Quinoline derivatives as intermediates to mycobacterial inhibitors | Janssen Pharmaceutica N.V. (BE) | 2011-03-30 | — | — | EP | disclosed |