Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.46 |
| ▸ | BDKRB1 | P46663 | 5/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 12/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 5/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.41 |
| ▸ | PRKAG3 | Q9UGI9 | 5/20 | 0.41 |
| ▸ | PRKAG2 | Q9UGJ0 | 5/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2240111 | 0.95 | MCHR1 (0.42) | MCHR1BDKRB1PRKAA2PRKAB2PRKAG1 | |
| SCHEMBL2239167 | 0.92 | KMT2A (0.45) | MCHR1BDKRB1KCNH2 | |
| SCHEMBL12347369 | 0.89 | MCHR1 (0.42) | MCHR1BDKRB1PRKAA2KCNH2 | |
| SCHEMBL12347370 | 0.89 | PPARD (0.44) | MCHR1BDKRB1PRKAA2PRKAB2PRKAG1 | |
| Trifluoroacetic Acid SCHEMBL2238978 | 0.87 | PPARD (0.46) | MCHR1BDKRB1PRKAA2PRKAB2PRKAG1 | |
| SCHEMBL2242580 | 0.87 | BDKRB1 (0.42) | MCHR1BDKRB1KCNH2 | |
| SCHEMBL2242220 | 0.86 | FAAH (0.51) | — | |
| Trifluoroacetic Acid SCHEMBL2242265 | 0.85 | PPARA (0.41) | MCHR1BDKRB1PRKAA2PRKAB2PRKAG1 | |
| SCHEMBL1935724 | 0.82 | BDKRB1 (0.45) | MCHR1BDKRB1KCNH2 | |
| SCHEMBL2237788 | 0.82 | BDKRB1 (0.44) | MCHR1BDKRB1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140073627-A1 | BRADYKININ B1 ANTAGONISTS | EVOTEC AG (DE) | 2014-03-13 | — | — | US | disclosed |
| US-20140073627-A1 | BRADYKININ B1 ANTAGONISTS | EVOTEC AG (DE) | 2014-03-13 | — | — | US | disclosed |
| US-8623859-B2 | Bradykinin B1 antagonists | EVOTEC AG (DE) | 2014-01-07 | — | — | US | disclosed |
| US-8623859-B2 | Bradykinin B1 antagonists | EVOTEC AG (DE) | 2014-01-07 | — | — | US | disclosed |
| US-20110201589-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC AG (DE) | 2011-08-18 | — | — | US | disclosed |
| US-20110201589-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC AG (DE) | 2011-08-18 | — | — | US | disclosed |
| WO-2010020556-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140073627-A1 | BRADYKININ B1 ANTAGONISTS | BDKRB1, BDKRB2, BRS3 | MCHR1 344/4885BDKRB1 1/4885PRKAA2 4047/4885 |
| US-20110201589-A1 | NEW BRADYKININ B1 ANTAGONISTS | BDKRB1, BDKRB2, BRS3 | MCHR1 366/4885BDKRB1 1/4885PRKAA2 4387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.