Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.36 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10272281 | 0.87 | POLB (0.38) | ALDH1A1LMNATSHRMAPK1AHR | |
| SCHEMBL20856365 | 0.83 | TDP1 (0.47) | ALDH1A1LMNATSHRMAPK1AHR | |
| SCHEMBL12213082 | 0.81 | ALDH1A1 (0.46) | ALDH1A1LMNATSHRMAPK1AHR | |
| SCHEMBL5626986 | 0.77 | POLB (0.42) | ALDH1A1TSHRMAPK1AHRCHUK | |
| SCHEMBL113455 | 0.76 | MAPK1 (0.44) | ALDH1A1TSHRMAPK1AHRCHUK | |
| SCHEMBL29445407 | 0.76 | MAPK1 (0.44) | ALDH1A1TSHRMAPK1AHRCHUK | |
| SCHEMBL10204664 | 0.75 | LMNA (0.39) | ALDH1A1LMNATSHRMAPK1MEN1 | |
| SCHEMBL12161659 | 0.74 | MAPK1 (0.42) | ALDH1A1TSHRMAPK1AHRCHUK | |
| SCHEMBL203312 | 0.74 | INPPL1 (0.46) | ALDH1A1TSHRMAPK1AHRCHUK | |
| SCHEMBL23272917 | 0.73 | POLB (0.38) | ALDH1A1LMNATSHRMAPK1AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2354126-A1 | Heteroaryl sulfonamides and CCR2 | ChemoCentryx, Inc. (US) | 2011-08-10 | — | — | EP | disclosed |