Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 11/20 | 0.64 |
| ▸ | DPP4 | P27487 | 8/20 | 0.50 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.48 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.48 |
| ▸ | FAP | Q12884 | 1/20 | 0.48 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12352126 | 0.92 | DPP7 (0.76) | DPP7DPP4DPP8DPP9FAP | |
| SCHEMBL12352125 | 0.85 | DPP7 (0.56) | DPP7DPP4DPP8DPP9FAP | |
| SCHEMBL12352122 | 0.83 | DPP7 (0.49) | DPP7DPP4DPP8DPP9FAP | |
| SCHEMBL23049149 | 0.83 | DPP4 (0.47) | DPP7DPP4GNAI3GNAO1GNAI1 | |
| SCHEMBL12351445 | 0.83 | DPP4 (0.47) | DPP7DPP4GNAI3GNAO1GNAI1 | |
| SCHEMBL30612344 | 0.82 | L3MBTL1 (0.51) | DPP7DPP4DPP8DPP9FAP | |
| SCHEMBL26039093 | 0.82 | DPP4 (0.51) | DPP7DPP4DPP8DPP9FAP | |
| SCHEMBL16417927 | 0.81 | DPP4 (0.46) | DPP7DPP4GNAI3GNAO1GNAI1 | |
| SCHEMBL25500916 | 0.81 | GNAI3 (0.50) | DPP7DPP4DPP8DPP9FAP | |
| SCHEMBL26040010 | 0.80 | DPP7 (0.46) | DPP7DPP4DPP8DPP9FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3786165-A1 | SYNTHETIC INTERMEDIATES FOR PRODUCING MACROCYCLES AS FACTOR XIA INHIBITORS | Bristol-Myers Squibb Company (US) | 2021-03-03 | — | — | EP | disclosed |
| EP-2534154-B1 | MACROCYCLES AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2020-08-05 | — | — | EP | disclosed |
| WO-2011100401-A1 | MACROCYCLES AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-08-18 | — | — | WO | disclosed |