Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | PI4KA | P42356 | 1/20 | 0.52 |
| ▸ | XDH | P47989 | 1/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.52 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.52 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26856850 | 0.77 | PDPK1 (0.50) | ALDH1A1RETPI4KAXDHLRRK2 | |
| SCHEMBL26854395 | 0.77 | MKNK1 (0.51) | ALDH1A1RETPI4KAXDHLRRK2 | |
| SCHEMBL25343796 | 0.76 | LMNA (0.57) | ALDH1A1RETPI4KAXDHLRRK2 | |
| SCHEMBL30568442 | 0.76 | LMNA (0.57) | ALDH1A1RETPI4KAXDHLRRK2 | |
| SCHEMBL18394456 | 0.75 | PLK4 (0.43) | ALDH1A1 | |
| SCHEMBL10226489 | 0.74 | ALDH1A1 (0.56) | ALDH1A1RETPI4KAXDHLRRK2 | |
| SCHEMBL1086048 | 0.71 | TTBK1 (0.60) | CSF1R | |
| Allopurinol SCHEMBL9245969 | 0.71 | CYP1A2 (0.54) | ALDH1A1RETPI4KAXDHLRRK2 | |
| SCHEMBL2619226 | 0.71 | RET (0.61) | ALDH1A1RETPI4KAXDHLRRK2 | |
| SCHEMBL11534318 | 0.70 | CCNE2 (0.49) | ALDH1A1RETLRRK2CHEK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809335-B2 | Pyrazolopyrimidine kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-08-19 | — | — | US | disclosed |
| US-8809335-B2 | Pyrazolopyrimidine kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-08-19 | — | — | US | disclosed |
| US-20130053394-A1 | PYRAZOLOPYRIMIDINE KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-02-28 | — | — | US | disclosed |
| US-20130053394-A1 | PYRAZOLOPYRIMIDINE KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-02-28 | — | — | US | disclosed |
| WO-2011094290-A1 | PYRAZOLOPYRIMIDINE KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053394-A1 | PYRAZOLOPYRIMIDINE KINASE INHIBITORS | MAP3K20, MAP3K5, MAP3K1 | ALDH1A1 3093/4885RET 428/4885PI4KA 109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.