Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | P2RY12 | Q9H244 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | OGG1 | O15527 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2244069 | 1.00 | ALDH1A1 (0.46) | ALDH1A1MAPTP2RY12KMT2AHSP90AA1 | |
| SCHEMBL9087240 | 0.88 | P2RY12 (0.42) | ALDH1A1P2RY12L3MBTL1ADAMTS4ADAMTS5 | |
| SCHEMBL9556410 | 0.88 | P2RY12 (0.42) | ALDH1A1P2RY12L3MBTL1ADAMTS4ADAMTS5 | |
| SCHEMBL9087244 | 0.88 | P2RY12 (0.42) | ALDH1A1P2RY12L3MBTL1ADAMTS4ADAMTS5 | |
| SCHEMBL9088792 | 0.85 | P2RY12 (0.43) | P2RY12L3MBTL1MMP2ADAMTS5 | |
| SCHEMBL9088784 | 0.85 | P2RY12 (0.43) | P2RY12L3MBTL1MMP2ADAMTS5 | |
| SCHEMBL27708443 | 0.85 | GRN (0.44) | ALDH1A1MAPTP2RY12KMT2AL3MBTL1 | |
| SCHEMBL9556190 | 0.84 | P2RY12 (0.41) | ALDH1A1MAPTP2RY12L3MBTL1ATM | |
| SCHEMBL2247466 | 0.84 | ADAMTS5 (0.44) | P2RY12MMP2ADAMTS4ADAMTS5 | |
| SCHEMBL9556181 | 0.84 | P2RY12 (0.41) | ALDH1A1MAPTP2RY12L3MBTL1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998965-B2 | Glutamate aggrecanase inhibitors | WYETH LLC (US) | 2011-08-16 | — | — | US | disclosed |