Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12359266 | 0.92 | SCD (0.42) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL12359272 | 0.88 | HDAC3 (0.43) | SCN5ASCN9AHDAC3HDAC4HDAC1 | |
| SCHEMBL12358670 | 0.86 | TRPV1 (0.43) | SCN5ASCN9ANPC1RAB9A | |
| SCHEMBL12653207 | 0.83 | SCN9A (0.37) | SCN5ASCN9A | |
| SCHEMBL12363936 | 0.83 | TRPV1 (0.46) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL12359212 | 0.82 | NPC1 (0.38) | SCDKDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL12358708 | 0.82 | RAB9A (0.50) | HDAC6SCDKDM4ENPC1ALDH1A1 | |
| SCHEMBL12359221 | 0.82 | SCD (0.44) | SCN5ASCN9AHDAC3HDAC4HDAC1 | |
| SCHEMBL12358860 | 0.81 | DGAT1 (0.53) | HDAC6SCDDGAT1KCNH2 | |
| SCHEMBL12358847 | 0.80 | TRPV1 (0.47) | SCN5ASCN9AHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110190344-A1 | BENZIMIDAZOLE MODULATORS OF VR1 | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190344-A1 | BENZIMIDAZOLE MODULATORS OF VR1 | VRK1, VRK2, VIL1 | SCN5A 1082/4885SCN9A 1573/4885HDAC3 1692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.