Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | C5AR1 | P21730 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | FABP3 | P05413 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12366306 | 0.91 | RXRA (0.47) | RXRANR1H2NR1H3KDM4EALDH1A1 | |
| SCHEMBL12366315 | 0.90 | ALDH1A1 (0.48) | RXRANR1H2NR1H3KDM4EALDH1A1 | |
| SCHEMBL12366439 | 0.90 | RXRA (0.40) | RXRANR1H2NR1H3TDP1KDM4E | |
| SCHEMBL12366218 | 0.90 | ALDH1A1 (0.41) | RXRANR1H2NR1H3TDP1KDM4E | |
| SCHEMBL12366281 | 0.89 | MDM2 (0.40) | RXRANR1H2NR1H3TDP1KDM4E | |
| SCHEMBL12366212 | 0.88 | CNR1 (0.44) | RXRANR1H2NR1H3KDM4EALDH1A1 | |
| SCHEMBL12366440 | 0.88 | RXRA (0.43) | RXRANR1H2NR1H3KDM4EALDH1A1 | |
| SCHEMBL12366488 | 0.88 | RXRA (0.39) | RXRANR1H2NR1H3KDM4EALDH1A1 | |
| SCHEMBL12366502 | 0.87 | RXRA (0.46) | RXRANR1H2NR1H3TDP1KDM4E | |
| SCHEMBL12366432 | 0.87 | RXRA (0.38) | RXRANR1H2NR1H3TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |