Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17B | O94768 | 1/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.32 |
| ▸ | JUN | P05412 | 3/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.32 |
| ▸ | RELA | Q04206 | 3/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | ATF1 | P18846 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | XPO1 | O14980 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12303887 | 0.87 | SYK (0.40) | STK17BSTK17ASYKUSP30NFKB1 | |
| SCHEMBL30964649 | 0.87 | SYK (0.34) | STK17BSTK17ASYKUSP30ATR | |
| SCHEMBL31326421 | 0.84 | STK17B (0.38) | STK17BSTK17ASYKUSP30NFKB1 | |
| SCHEMBL17133463 | 0.80 | CKS1B (0.41) | STK17BSTK17ASYKNFKB1JUN | |
| SCHEMBL25323395 | 0.79 | STK17B (0.45) | STK17BSTK17ASYKUSP30NFKB1 | |
| SCHEMBL30550836 | 0.79 | STK17B (0.45) | STK17BSTK17ASYKUSP30NFKB1 | |
| SCHEMBL12332862 | 0.78 | SYK (0.38) | STK17BSTK17ASYKNFKB1JUN | |
| SCHEMBL26975222 | 0.78 | SYK (0.40) | STK17BSTK17ASYKUSP30NFKB1 | |
| SCHEMBL23094630 | 0.78 | MT-CO2 (0.38) | STK17BSTK17ASYKUSP30NFKB1 | |
| SCHEMBL17111666 | 0.77 | SYK (0.37) | SYKNFKB1NFKB2RELAPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230242551-A1 | ISOTOPE-SUBSTITUTED SPIRO AROMATIC RING COMPOUND AND APPLICATION THEREOF | ETERN BIOPHARMA (SHANGHAI) CO., LTD. (CN) | 2023-08-03 | — | — | US | disclosed |
| EP-4166549-A1 | ISOTOPE-SUBSTITUTED SPIRO AROMATIC RING COMPOUND AND APPLICATION THEREOF | Etern Biopharma (Shanghai) Co., Ltd. (CN) | 2023-04-19 | — | — | EP | disclosed |
| US-9815846-B2 | TrkA kinase inhibitors, compositions and methods thereof | MERCK SHARP & DOHME CORP. (US) | 2017-11-14 | — | — | US | disclosed |
| US-20170114071-A1 | TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME CORP. (US) | 2017-04-27 | — | — | US | disclosed |
| WO-2015148344-A2 | TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME CORP. (US) | 2015-10-01 | — | — | WO | disclosed |
| US-8735424-B2 | Bicyclic kinase inhibitors | NOVARTIS AG (CH) | 2014-05-27 | — | — | US | disclosed |
| US-8735424-B2 | Bicyclic kinase inhibitors | NOVARTIS AG (CH) | 2014-05-27 | — | — | US | disclosed |
| US-20110195980-A1 | Bicyclic Kinase Inhibitors | NOVARTIS AG (CH) | 2011-08-11 | — | — | US | disclosed |
| US-20110195980-A1 | Bicyclic Kinase Inhibitors | NOVARTIS AG (CH) | 2011-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170114071-A1 | TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | NGFR, NGF, NTRK1 | STK17B 1021/4885STK17A 785/4885SYK 159/4885 |
| US-20230242551-A1 | ISOTOPE-SUBSTITUTED SPIRO AROMATIC RING COMPOUND AND APPLICATION THEREOF | SLCO1B1, SLCO1B3, SLCO2B1 | STK17B 874/4885STK17A 675/4885SYK 1628/4885 |
| US-20110195980-A1 | Bicyclic Kinase Inhibitors | PIM1, PIM2, PIM3 | STK17B 200/4885STK17A 176/4885SYK 552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.