Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | BPTF | Q12830 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27988904 | 0.81 | TACR1 (0.35) | KDM1AHTR2AHTR2CHTR2BCHRNB2 | |
| SCHEMBL12371293 | 0.79 | GBA1 (0.57) | GBA1KDM1AMAOASLC18A3SIGMAR1 | |
| SCHEMBL28524489 | 0.76 | GBA1 (0.46) | GBA1KDM1ASLC18A3SIGMAR1MEN1 | |
| SCHEMBL31374602 | 0.76 | GBA1 (0.46) | GBA1KDM1ASLC18A3SIGMAR1MEN1 | |
| SCHEMBL4425525 | 0.74 | HTR2C (0.34) | HTR2AHTR2CHTR2BKCNH2 | |
| SCHEMBL27878041 | 0.73 | CHRNA7 (0.51) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| SCHEMBL5699973 | 0.71 | MAOA (0.49) | BPTFKDM1AMAOAHTR2AHTR2C | |
| SCHEMBL2329363 | 0.71 | MAOA (0.49) | BPTFKDM1AMAOAHTR2AHTR2C | |
| SCHEMBL6925312 | 0.70 | BPTF (0.43) | BPTFKDM1AMAOASLC18A3SIGMAR1 | |
| SCHEMBL7076302 | 0.70 | CYP11B2 (0.44) | BPTFKDM1AMAOASLC18A3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9157077-B2 | Aminopyrimidine kinase inhibitors | Jasco Pharmaceuticals, LLC (US) | 2015-10-13 | — | — | US | disclosed |
| US-9073903-B2 | Imidazole-2,4-dione inhibitors of casein kinase 1 | Jasco Pharmaceuticals, LLC (US) | 2015-07-07 | — | — | US | disclosed |
| US-20140080799-A1 | Aminopyrimidine Kinase Inhibitors | Jasco Pharmaceuticals, LLC (US) | 2014-03-20 | — | — | US | disclosed |
| US-8563539-B2 | Aminopyrimidine kinase inhibitors | Jasco Pharmaceuticals, LLC (US) | 2013-10-22 | — | — | US | disclosed |
| US-20120316155-A1 | Imidazole-2,4-Dione Inhibitors of Casein Kinase 1 | Jasco Pharmaceuticals, LLC (US) | 2012-12-13 | — | — | US | disclosed |
| US-20110152235-A1 | Aminopyrimidine Kinase Inhibitors | Jasco Pharmaceuticals, LLC (US) | 2011-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140080799-A1 | Aminopyrimidine Kinase Inhibitors | PIM1, PIM2, PIM3 | GBA1 4741/4885BPTF 2308/4885KDM1A 1208/4885 |
| US-20110152235-A1 | Aminopyrimidine Kinase Inhibitors | PIM1, PIM2, PIM3 | GBA1 4735/4885BPTF 2279/4885KDM1A 1229/4885 |
| US-20120316155-A1 | Imidazole-2,4-Dione Inhibitors of Casein Kinase 1 | CSNK1G1, CSNK1A1, CSNK1G3 | GBA1 4410/4885BPTF 2432/4885KDM1A 825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.