Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31374602 | 1.00 | GBA1 (0.46) | GBA1NLRP3SLC18A3SIGMAR1TSHR | |
| SCHEMBL11282740 | 0.84 | TSHR (0.42) | GBA1NLRP3SLC18A3SIGMAR1TSHR | |
| SCHEMBL31135958 | 0.80 | HNF4A (0.41) | TSHRKMT2A | |
| SCHEMBL27468224 | 0.79 | ESR2 (0.38) | KIF11 | |
| SCHEMBL31668418 | 0.78 | MAOA (0.35) | MAOB | |
| SCHEMBL12371293 | 0.78 | GBA1 (0.57) | GBA1SLC18A3SIGMAR1TSHRMEN1 | |
| SCHEMBL24774608 | 0.77 | PRCP (0.37) | NLRP3PRCP | |
| SCHEMBL22781481 | 0.76 | TSHR (0.40) | GBA1SLC18A3TSHRKDM1APRCP | |
| SCHEMBL2030993 | 0.76 | GBA1 (0.47) | GBA1SLC18A3SIGMAR1MEN1KMT2A | |
| SCHEMBL28232790 | 0.73 | PRCP (0.37) | TSHRMEN1KMT2APRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117683029-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117430601-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-112437772-B | Bcl-2 inhibitors | 百济神州有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-112437772-A | Bcl-2 inhibitors | 百济神州有限公司 | 2021-03-02 | — | — | CN | disclosed |