SCHEMBL12371296

SCHEMBL12371296

c1ccc(C2CC3CNC(c4ccccc4)CC3CN2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRCP P42785 1/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
GBA1 P04062 1/20 0.39
MAOA P21397 6/20 0.38
MAOB P27338 6/20 0.38
KDM1A O60341 4/20 0.38
CYP2C19 P33261 4/20 0.38
CYP2B6 P20813 3/20 0.38
CYP1A2 P05177 2/20 0.38
CYP2D6 P10635 2/20 0.38
CYP2C9 P11712 2/20 0.38
LMNA P02545 1/20 0.38
CYP3A4 P08684 1/20 0.38
HTR1A P08908 1/20 0.38
ADRA2A P08913 1/20 0.38
CYP2A6 P11509 1/20 0.38
SLC6A2 P23975 1/20 0.38
HTR2C P28335 1/20 0.38
ADRA1A P35348 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26984134 0.94 PRCP (0.40) PRCPMEN1KMT2AGBA1
SCHEMBL11498727 0.86 SLC18A3 (0.39) PRCPMEN1KMT2A
SCHEMBL11498726 0.86 SLC18A3 (0.39) PRCPMEN1KMT2A
SCHEMBL11498780 0.86 SLC18A3 (0.39) PRCPMEN1KMT2A
SCHEMBL8535631 0.83
SCHEMBL1688451 0.83
SCHEMBL369386 0.83
SCHEMBL15670538 0.80 PRCP (0.50) PRCPMEN1KMT2AGBA1
SCHEMBL1893741 0.80 PRCP (0.50) PRCPMEN1KMT2AGBA1
SCHEMBL14972873 0.80 PRCP (0.50) PRCPMEN1KMT2AGBA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110202328-A1 System for the determination of selective absorbent molecules through predictive correlations EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) 2011-08-18 US disclosed
US-20110202328-A1 System for the determination of selective absorbent molecules through predictive correlations EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) 2011-08-18 US disclosed