Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bupropion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 8/20 | 1.00 |
| ▸ | SLC6A3 known ✓ | Q01959 | 10/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | CHRNA1 | P02708 | 5/20 | 0.97 |
| ▸ | CHRNG | P07510 | 5/20 | 0.97 |
| ▸ | CHRNB1 | P11230 | 5/20 | 0.97 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.97 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.97 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.97 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.97 |
| ▸ | CHRND | Q07001 | 5/20 | 0.97 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.97 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.97 |
| ▸ | HRH1 | P35367 | 1/20 | 0.97 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.97 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bupropion SCHEMBL31748783 | 1.00 | SLC6A2 (1.00) | SLC6A2ALDH1A1BLMSMN1; SMN2SLC6A3 | |
| Bupropion SCHEMBL29682406 | 1.00 | SLC6A2 (1.00) | SLC6A2ALDH1A1BLMSMN1; SMN2SLC6A3 | |
| Bupropion SCHEMBL5075866 | 1.00 | SLC6A2 (1.00) | SLC6A2ALDH1A1BLMSMN1; SMN2SLC6A3 | |
| Bupropion SCHEMBL41602 | 1.00 | SLC6A2 (1.00) | SLC6A2ALDH1A1BLMSMN1; SMN2SLC6A3 | |
| Bupropion SCHEMBL29420039 | 1.00 | SLC6A2 (1.00) | SLC6A2ALDH1A1BLMSMN1; SMN2SLC6A3 | |
| Bupropion SCHEMBL12499296 | 0.98 | SLC6A3 (1.00) | SLC6A2ALDH1A1BLMSMN1; SMN2SLC6A3 | |
| Bupropion SCHEMBL30679332 | 0.98 | SLC6A3 (1.00) | SLC6A2ALDH1A1BLMSMN1; SMN2SLC6A3 | |
| Bupropion SCHEMBL38777 | 0.98 | SLC6A3 (1.00) | SLC6A2ALDH1A1BLMSMN1; SMN2SLC6A3 | |
| Bupropion SCHEMBL300444 | 0.98 | SLC6A3 (1.00) | SLC6A2ALDH1A1BLMSMN1; SMN2SLC6A3 | |
| Bupropion SCHEMBL29354885 | 0.98 | SLC6A3 (1.00) | SLC6A2ALDH1A1BLMSMN1; SMN2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7884136-B2 | Modified-release formulations of a bupropion salt | BIOVAIL LABORATORIES INTERNATIONAL S.R.L. (BB) | 2011-02-08 | — | — | US | disclosed |