Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bupropion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 8/20 | 1.00 |
| ▸ | SLC6A3 known ✓ | Q01959 | 10/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | CHRNA1 | P02708 | 5/20 | 0.97 |
| ▸ | CHRNG | P07510 | 5/20 | 0.97 |
| ▸ | CHRNB1 | P11230 | 5/20 | 0.97 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.97 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.97 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.97 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.97 |
| ▸ | CHRND | Q07001 | 5/20 | 0.97 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.97 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.97 |
| ▸ | HRH1 | P35367 | 1/20 | 0.97 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.97 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bupropion SCHEMBL31748783 | 1.00 | SLC6A2 (1.00) | SLC6A2ALDH1A1BLMSMN1; SMN2SLC6A3 | |
| Bupropion SCHEMBL5075866 | 1.00 | SLC6A2 (1.00) | SLC6A2ALDH1A1BLMSMN1; SMN2SLC6A3 | |
| Bupropion SCHEMBL29420039 | 1.00 | SLC6A2 (1.00) | SLC6A2ALDH1A1BLMSMN1; SMN2SLC6A3 | |
| Bupropion SCHEMBL41602 | 1.00 | SLC6A2 (1.00) | SLC6A2ALDH1A1BLMSMN1; SMN2SLC6A3 | |
| Bupropion SCHEMBL1237221 | 1.00 | SLC6A2 (1.00) | SLC6A2ALDH1A1BLMSMN1; SMN2SLC6A3 | |
| Bupropion SCHEMBL300444 | 0.98 | SLC6A3 (1.00) | SLC6A2ALDH1A1BLMSMN1; SMN2SLC6A3 | |
| Bupropion SCHEMBL30679332 | 0.98 | SLC6A3 (1.00) | SLC6A2ALDH1A1BLMSMN1; SMN2SLC6A3 | |
| Bupropion SCHEMBL38777 | 0.98 | SLC6A3 (1.00) | SLC6A2ALDH1A1BLMSMN1; SMN2SLC6A3 | |
| Bupropion SCHEMBL29354885 | 0.98 | SLC6A3 (1.00) | SLC6A2ALDH1A1BLMSMN1; SMN2SLC6A3 | |
| Bupropion SCHEMBL12499296 | 0.98 | SLC6A3 (1.00) | SLC6A2ALDH1A1BLMSMN1; SMN2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122094687-A | Compounds and combinations thereof for the treatment of neurological and psychiatric disorders | — | 2026-05-26 | — | — | CN | disclosed |
| CN-119497617-A | Compounds and combinations thereof for the treatment of neurological and psychiatric conditions | 安泰赛普生物风投二代有限责任公司 | 2025-02-21 | — | — | CN | disclosed |
| CN-119486722-A | Bupropion dosage forms with reduced food and alcohol dose effects | 安泰赛普生物风投二代有限责任公司 | 2025-02-18 | — | — | CN | disclosed |
| CN-119486723-A | Treatment of dextromethorphan poor metabolizers using a combination of bupropion and dextromethorphan | 安泰赛普生物风投二代有限责任公司 | 2025-02-18 | — | — | CN | disclosed |
| CN-119212709-A | Treatment of depression | 安泰赛普生物风投二代有限责任公司 | 2024-12-27 | — | — | CN | disclosed |
| CN-114874084-B | Preparation method of bupropion hydrochloride impurity F | 浙江普洛家园药业有限公司 | 2023-12-19 | — | — | CN | disclosed |