Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 8/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.35 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.34 |
| ▸ | TDP2 | O95551 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAT2A | P31153 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12373979 | 0.77 | HTR2C (0.47) | — | |
| Hydrochloric Acid SCHEMBL2280238 | 0.75 | HTR2C (0.49) | — | |
| SCHEMBL11996732 | 0.75 | TDP2 (0.53) | NR1H2NR1H3NPC1RAB9ATDP2 | |
| SCHEMBL12373867 | 0.74 | PSMB5 (0.40) | PSMB5NPC1RAB9AACMSDTDP1 | |
| SCHEMBL10793933 | 0.72 | ACMSD (0.53) | PSMB5ACMSDTDP1PTGS2 | |
| SCHEMBL17953961 | 0.72 | KDM4C (0.55) | NR1H2NR1H3NPC1RAB9ATDP2 | |
| SCHEMBL2273828 | 0.72 | AHR (0.49) | NR1H2NR1H3NPC1RAB9ATDP2 | |
| SCHEMBL2644692 | 0.72 | KDM4C (0.55) | NR1H2NR1H3NPC1RAB9ATDP2 | |
| SCHEMBL16202035 | 0.71 | NR1H3 (0.71) | NR1H2NR1H3NPC1RAB9ATDP2 | |
| SCHEMBL10991732 | 0.70 | PSMB5 (0.47) | PSMB5ACMSDPSMB1TDP1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8716483-B2 | Compounds that are ERK inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-05-06 | — | — | US | disclosed |
| US-20110189192-A1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | MERCK SHARP & DOHME LLC | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110189192-A1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | MAPK1, MAPK4, MAPK10 | PSMB5 3724/4885NR1H2 1153/4885NR1H3 1278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.