SCHEMBL12374328

SCHEMBL12374328

COc1ccc(C2(c3ccc(OC)c(C)c3)c3cc(C)ccc3-c3ccc(C)cc32)cc1C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.44
ALDH1A1 P00352 3/20 0.41
CYP3A4 P08684 1/20 0.41
ESR1 P03372 1/20 0.41
ESR2 Q92731 1/20 0.41
NQO2 P16083 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.37
LMNA P02545 2/20 0.37
KDM4E B2RXH2 1/20 0.37
MDM2 Q00987 1/20 0.37
L3MBTL1 Q9Y468 2/20 0.35
BACE1 P56817 3/20 0.34
POLB P06746 2/20 0.34
MAPT P10636 2/20 0.34
NPC1 O15118 1/20 0.34
G6PD P11413 1/20 0.34
PKM P14618 1/20 0.34
RAB9A P51151 1/20 0.34
GAA P10253 1/20 0.34
MPI P34949 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12374347 0.89 ACHE (0.55) ACHEALDH1A1CYP3A4SMN1; SMN2LMNA
SCHEMBL4760269 0.84 NQO2 (0.41) ALDH1A1ESR1ESR2NQO2SMN1; SMN2
SCHEMBL18415977 0.82 ESR1 (0.61) ALDH1A1ESR1ESR2NQO2SMN1; SMN2
SCHEMBL13494976 0.81 ALDH1A1 (0.41) ACHEALDH1A1SMN1; SMN2KDM4EL3MBTL1
SCHEMBL12374330 0.80 ESR1 (0.41) ALDH1A1ESR1ESR2SMN1; SMN2LMNA
SCHEMBL13400898 0.80 HSP90AA1 (0.44) ACHEALDH1A1LMNAKDM4EL3MBTL1
SCHEMBL12374341 0.78 ACHE (0.48) ACHEL3MBTL1MAPTNPC1RAB9A
SCHEMBL12924685 0.78 ESR1 (0.43) ALDH1A1ESR1SMN1; SMN2KDM4EL3MBTL1
SCHEMBL12924691 0.78 ESR1 (0.43) ALDH1A1ESR1SMN1; SMN2KDM4EL3MBTL1
SCHEMBL13828491 0.77 ACHE (0.52) ACHEALDH1A1LMNAKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110187266-A1 POLYMER COMPOUND AND LIGHT EMITTING DEVICE USING THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-08-04 US disclosed