SCHEMBL12374474

SCHEMBL12374474

Cc1cc(=O)nc(NC(=O)NC(CCCC(NC(=O)Nc2nc(=O)cc(C)[nH]2)C(=O)O)C(=O)O)[nH]1

nearest known ligand 0.38

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ ABL1 P00519 4/20 0.37
▸ FPR2 P25090 1/20 0.37
▸ MAPK1 P28482 2/20 0.36
▸ NPSR1 Q6W5P4 1/20 0.35
▸ NOD1 Q9Y239 1/20 0.35
▸ PYGL P06737 2/20 0.34
▸ CYP2C9 P11712 1/20 0.34
▸ FOLH1 Q04609 3/20 0.33
▸ C3AR1 Q16581 1/20 0.33
▸ PIN1 Q13526 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12462486 0.92 FOLH1 (0.45) PYGLFOLH1
SCHEMBL12374471 0.91 FOLH1 (0.46) ABL1FOLH1
SCHEMBL21065294 0.90 NAALAD2 (0.47) FPR2FOLH1
SCHEMBL12462485 0.90 NAALAD2 (0.47) FPR2FOLH1
SCHEMBL12462479 0.88 JAK2 (0.41) ABL1FPR2PYGLFOLH1
SCHEMBL12374469 0.88 USP2 (0.40) —
SCHEMBL21065264 0.84 TDP1 (0.43) NPSR1
SCHEMBL21065266 0.84 TDP1 (0.43) NPSR1
SCHEMBL12374464 0.81 TUBB4A (0.33) ABL1
SCHEMBL13051269 0.80 GAA (0.38) ABL1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11141368-B2 Cosmetic composition, cosmetic treatment method, kit, and compound L'OREAL (FR) 2021-10-12 — — US disclosed
US-10813866-B2 Cosmetic composition, cosmetic treatment method, kit, and compound L'OREAL (FR) 2020-10-27 — — US disclosed
EP-2521530-B1 COSMETIC COMPOSITION, COSMETIC TREATMENT METHOD, KIT, AND COMPOUND OREAL (FR) 2019-06-26 — — EP disclosed
US-8575341-B2 Cosmetic composition, cosmetic treatment method, and compound L'OREAL (FR) 2013-11-05 — — US disclosed
US-8575341-B2 Cosmetic composition, cosmetic treatment method, and compound L'OREAL (FR) 2013-11-05 — — US disclosed
US-20130017162-A1 COSMETIC COMPOSITION, COSMETIC TREATMENT METHOD, KIT, AND COMPOUND L'OREAL (FR) 2013-01-17 — — US disclosed
US-20130017162-A1 COSMETIC COMPOSITION, COSMETIC TREATMENT METHOD, KIT, AND COMPOUND L'OREAL (FR) 2013-01-17 — — US disclosed
US-20110189118-A1 COSMETIC COMPOSITION, COSMETIC TREATMENT METHOD, AND COMPOUND L'OREAL (FR) 2011-08-04 — — US disclosed
US-20110189118-A1 COSMETIC COMPOSITION, COSMETIC TREATMENT METHOD, AND COMPOUND L'OREAL (FR) 2011-08-04 — — US disclosed
WO-2011080494-A2 COSMETIC COMPOSITION, COSMETIC TREATMENT METHOD, KIT, AND COMPOUND L'OREAL (FR) 2011-07-07 — — WO disclosed
WO-2010001041-A2 COSMETIC COMPOSITION, COSMETIC TREATMENT METHOD, AND COMPOUND L'OREAL (FR) 2010-01-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130017162-A1 COSMETIC COMPOSITION, COSMETIC TREATMENT METHOD, KIT, AND COMPOUND KRT18, KIT, TYR ABL1 1039/4885FPR2 1666/4885MAPK1 969/4885
US-20110189118-A1 COSMETIC COMPOSITION, COSMETIC TREATMENT METHOD, AND COMPOUND KRT18, MC1R, C1R ABL1 4705/4885FPR2 1609/4885MAPK1 2828/4885
US-10813866-B2 Cosmetic composition, cosmetic treatment method, kit, and compound KRT18, KIT, TYR ABL1 1039/4885FPR2 1666/4885MAPK1 969/4885
US-11141368-B2 Cosmetic composition, cosmetic treatment method, kit, and compound KRT18, KIT, TYR ABL1 1039/4885FPR2 1666/4885MAPK1 969/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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