Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 2/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2275784 | 1.00 | LMNA (0.43) | LMNAHTTMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL2284512 | 0.89 | LMNA (0.51) | LMNAHTTMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL12374659 | 0.89 | LMNA (0.51) | LMNAHTTMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL2284238 | 0.85 | LMNA (0.41) | LMNAHTTMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL12374658 | 0.83 | NPC1 (0.48) | LMNAMAPTSMN1; SMN2NPSR1MEN1 | |
| SCHEMBL2279274 | 0.83 | NPC1 (0.48) | LMNAMAPTSMN1; SMN2NPSR1MEN1 | |
| SCHEMBL3530413 | 0.82 | MAPT (0.58) | HTTMAPTSMN1; SMN2NPSR1MEN1 | |
| SCHEMBL13403229 | 0.82 | MAPT (0.58) | HTTMAPTSMN1; SMN2NPSR1MEN1 | |
| SCHEMBL2277552 | 0.82 | RAB9A (0.51) | LMNAHTTSMN1; SMN2NPSR1MEN1 | |
| SCHEMBL2277561 | 0.82 | RAB9A (0.51) | LMNAHTTSMN1; SMN2NPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989478-B2 | decreases expression of a Type I collage gene in a tissue to induce a reduction in accumulation of collagen and thereby improves tissue fibrosis | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-08-02 | — | — | US | disclosed |
| US-7989478-B2 | decreases expression of a Type I collage gene in a tissue to induce a reduction in accumulation of collagen and thereby improves tissue fibrosis | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-08-02 | — | — | US | disclosed |