Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21540402 | 0.86 | ALDH1A1 (0.51) | PIK3CDALDH1A1SMN1; SMN2ACSS2TDP1 | |
| SCHEMBL1463815 | 0.79 | CYP3A4 (0.53) | PIK3CDALDH1A1SMN1; SMN2KDM4EPOLB | |
| SCHEMBL14344232 | 0.78 | MAPT (0.69) | PIK3CDALDH1A1SMN1; SMN2ACSS2TDP1 | |
| SCHEMBL12317672 | 0.78 | KDM4E (0.48) | ACSS2MAPTFGFR1KDM4ENPC1 | |
| SCHEMBL12269122 | 0.78 | HDAC6 (0.43) | ALDH1A1SMN1; SMN2MAPTKDM4ENPC1 | |
| SCHEMBL25443596 | 0.77 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2ACSS2TDP1MAPT | |
| SCHEMBL3613367 | 0.77 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2TDP1MAPTFGFR1 | |
| SCHEMBL3965377 | 0.77 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2ACSS2TDP1MAPT | |
| SCHEMBL12869467 | 0.77 | ESR1 (0.46) | SMN1; SMN2FGFR1KDM4ECNR2KMT2A | |
| SCHEMBL4790064 | 0.77 | MEN1 (0.42) | PIK3CDALDH1A1MAPTPIK3CBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110201607-A1 | FUSED HETEROCYCLIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck, Sharp & Dohme, Corp. | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201607-A1 | FUSED HETEROCYCLIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | CHRM1, OPRL1, OPRM1 | PIK3CD 767/4885ALDH1A1 2852/4885SMN1; SMN2 1266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.