Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12409534 | 0.84 | ALDH1A1 (0.67) | ALDH1A1KDM4ESMN1; SMN2HSD17B10MAPT | |
| SCHEMBL21274521 | 0.82 | PIN1 (0.57) | ALDH1A1KDM4ESMN1; SMN2HSD17B10MAPT | |
| SCHEMBL21274517 | 0.82 | PIN1 (0.57) | ALDH1A1KDM4ESMN1; SMN2HSD17B10MAPT | |
| SCHEMBL10035809 | 0.82 | ALDH1A1 (0.64) | ALDH1A1KDM4ESMN1; SMN2HSD17B10MAPT | |
| SCHEMBL5307911 | 0.81 | KDM4E (0.74) | ALDH1A1KDM4ESMN1; SMN2HSD17B10MAPT | |
| SCHEMBL17773180 | 0.81 | ALDH1A1 (0.62) | ALDH1A1KDM4ESMN1; SMN2HSD17B10MAPT | |
| SCHEMBL10337354 | 0.79 | ALDH1A1 (0.68) | ALDH1A1KDM4ESMN1; SMN2HSD17B10MAPT | |
| SCHEMBL15685943 | 0.78 | ALDH1A1 (0.74) | ALDH1A1KDM4ESMN1; SMN2HSD17B10MAPT | |
| SCHEMBL22640049 | 0.78 | ALDH1A1 (0.59) | ALDH1A1KDM4ESMN1; SMN2HSD17B10MAPT | |
| SCHEMBL22640060 | 0.78 | HTT (0.64) | ALDH1A1KDM4ESMN1; SMN2HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003662-B2 | Heterobicyclic thiophene compounds and methods of use | ARRAY BIOPHARMA, INC. (US) | 2011-08-23 | — | — | US | disclosed |
| WO-2008063202-A2 | HETEROBICYCLIC THIOPHENE COMPOUNDS FOR THE TREATMENT OF CANCER | ARRAY BIOPHARMA INC. (US) | 2008-05-29 | — | — | WO | disclosed |
| US-20070197537-A1 | Heterobicyclic thiophene compounds and methods of use | ARRAY BIOPHARMA, INC. | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197537-A1 | Heterobicyclic thiophene compounds and methods of use | ERBB2, LCK, SRC | ALDH1A1 1635/4885KDM4E 3968/4885SMN1; SMN2 2264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.