Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | USP2 | O75604 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CCND2 | P30279 | 1/20 | 0.42 |
| ▸ | CCND3 | P30281 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18722088 | 0.85 | BPTF (0.44) | CYP1A2CYP2C9CYP2D6ALDH1A1KDM4E | |
| SCHEMBL12411881 | 0.82 | BRD4 (0.44) | CYP1A2CYP3A4CYP2C9CYP2D6ALDH1A1 | |
| SCHEMBL12561198 | 0.81 | CYP1A2 (0.48) | CYP1A2CYP3A4CYP2C9CYP2D6ALDH1A1 | |
| SCHEMBL2278282 | 0.80 | WEE1 (0.45) | CYP1A2CYP3A4CYP2C9CYP2D6ALDH1A1 | |
| SCHEMBL11481093 | 0.80 | ALDH1A1 (0.47) | CYP1A2CYP3A4CYP2C9CYP2D6ALDH1A1 | |
| SCHEMBL12848057 | 0.79 | CDK4 (0.45) | CYP1A2CYP3A4CYP2C9CYP2D6ALDH1A1 | |
| SCHEMBL12376775 | 0.78 | GAA (0.58) | CYP1A2CYP3A4CYP2C9CYP2D6ALDH1A1 | |
| SCHEMBL3116997 | 0.72 | CDK4 (0.50) | CYP1A2CYP3A4CYP2C9CYP2D6ALDH1A1 | |
| SCHEMBL2282607 | 0.69 | MET (0.47) | WEE1MET | |
| SCHEMBL13116045 | 0.69 | MET (0.58) | CYP1A2ALDH1A1USP2MAPK1WEE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003662-B2 | Heterobicyclic thiophene compounds and methods of use | ARRAY BIOPHARMA, INC. (US) | 2011-08-23 | — | — | US | disclosed |
| US-20070197537-A1 | Heterobicyclic thiophene compounds and methods of use | ARRAY BIOPHARMA, INC. | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197537-A1 | Heterobicyclic thiophene compounds and methods of use | ERBB2, LCK, SRC | CYP1A2 1021/4885CYP3A4 1118/4885CYP2C9 712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.