⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13193510 | 1.00 | — | — | |
| SCHEMBL18235465 | 0.83 | — | — | |
| SCHEMBL12377071 | 0.82 | — | — | |
| SCHEMBL12377077 | 0.82 | — | — | |
| SCHEMBL24564797 | 0.79 | EPHX1 (0.50) | — | |
| SCHEMBL20244269 | 0.79 | EPHX1 (0.50) | — | |
| SCHEMBL21105826 | 0.79 | EPHX1 (0.50) | — | |
| SCHEMBL7161671 | 0.79 | ALDH1A1 (0.36) | — | |
| SCHEMBL7161675 | 0.79 | ALDH1A1 (0.36) | — | |
| SCHEMBL19293311 | 0.78 | ALDH1A1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008440-B2 | Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery | TRANZYME PHARMA INC. (CA) | 2011-08-30 | — | — | US | disclosed |
| US-20070117154-A1 | Cyclic lactams comprising three amino acids and a tether chain to control the overall shape of the macromolecule; beta-turn mimetics to explore conformationally restricted structures; proteolytic enzyme resistance (nonhydrolyzing); cell penetration; anticoagulants; anticarcinogenic agents | MALLINCKRODT PHARMACEUTICALS IRELAND LIMITED (IE) | 2007-05-24 | — | — | US | disclosed |