Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.85 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 3/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.44 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL429588 | 0.92 | BRAF (1.00) | BRAFHSP90AB1MEN1KMT2AHPGD | |
| SCHEMBL2287561 | 0.90 | BRAF (0.89) | BRAFHSP90AB1MEN1KMT2AHPGD | |
| SCHEMBL1774806 | 0.90 | BRAF (0.87) | BRAFHSP90AB1MEN1KMT2AHPGD | |
| SCHEMBL18537731 | 0.90 | BRAF (0.87) | BRAFHSP90AB1MEN1KMT2AHPGD | |
| SCHEMBL12600461 | 0.86 | BRAF (0.84) | BRAFHSP90AB1MEN1KMT2AHPGD | |
| SCHEMBL2288722 | 0.85 | BRAF (0.80) | BRAFHSP90AB1MEN1KMT2AHPGD | |
| SCHEMBL2289195 | 0.85 | BRAF (0.80) | BRAFHSP90AB1MEN1KMT2AHPGD | |
| SCHEMBL1776548 | 0.85 | BRAF (0.87) | BRAFHSP90AB1MEN1KMT2AHPGD | |
| SCHEMBL14962911 | 0.85 | BRAF (0.87) | BRAFHSP90AB1MEN1KMT2AHPGD | |
| SCHEMBL14955091 | 0.85 | BRAF (0.87) | BRAFHSP90AB1MEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989625-B2 | Thienopyridines | MERCK PATENT GMBH (DE) | 2011-08-02 | — | — | US | disclosed |
| US-7989625-B2 | Thienopyridines | MERCK PATENT GMBH (DE) | 2011-08-02 | — | — | US | disclosed |
| US-20100048558-A1 | THIENOPYRIDINES | MERCK PATENT GESELLSCHAFT (DE) | 2010-02-25 | — | — | US | disclosed |
| US-20100048558-A1 | THIENOPYRIDINES | MERCK PATENT GESELLSCHAFT (DE) | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048558-A1 | THIENOPYRIDINES | HSP90AB2P, HSP90AB1, HSP90AA1 | BRAF 2033/4885HSP90AB1 2/4885MEN1 4504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.