Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 1.00 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | USP2 | O75604 | 2/20 | 0.52 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2287561 | 0.94 | BRAF (0.89) | BRAFHSP90AB1MEN1KMT2AALDH1A1 | |
| SCHEMBL18537731 | 0.93 | BRAF (0.87) | BRAFHSP90AB1MEN1KMT2AALDH1A1 | |
| SCHEMBL1774806 | 0.93 | BRAF (0.87) | BRAFHSP90AB1MEN1KMT2AALDH1A1 | |
| SCHEMBL14955091 | 0.93 | BRAF (0.87) | BRAFHSP90AB1MEN1KMT2AALDH1A1 | |
| SCHEMBL1776548 | 0.93 | BRAF (0.87) | BRAFHSP90AB1MEN1KMT2AALDH1A1 | |
| SCHEMBL14962911 | 0.93 | BRAF (0.87) | BRAFHSP90AB1MEN1KMT2AALDH1A1 | |
| SCHEMBL12377464 | 0.92 | BRAF (0.85) | BRAFHSP90AB1MEN1KMT2AALDH1A1 | |
| SCHEMBL12600461 | 0.92 | BRAF (0.84) | BRAFHSP90AB1MEN1KMT2AALDH1A1 | |
| SCHEMBL12600733 | 0.90 | BRAF (0.82) | BRAFHSP90AB1MEN1KMT2AALDH1A1 | |
| SCHEMBL19000369 | 0.90 | BRAF (0.82) | BRAFHSP90AB1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054452-A1 | Thienopyridine Derivatives and the Use Thereof as Hsp90 Modulators | MERCK PATENT GMBH (DE) | 2009-02-26 | — | — | US | claimed |
| EP-1853609-A1 | THIENOPYRIDINE DERIVATIVES AND USE THEREOF AS HSP90 MODULATORS | Merck Patent GmbH (DE) | 2007-11-14 | — | — | EP | claimed |
| WO-2006092202-A1 | THIENOPYRIDINE DERIVATIVES AND USE THEREOF AS HSP90 MODULATORS | MERCK PATENT GMBH (DE) | 2006-09-08 | — | — | WO | claimed |
| US-20180015077-A1 | COMPOUNDS AND METHODS FOR TREATING HIV INFECTION | NAKAMURA, ROBERT | 2018-01-18 | — | — | US | disclosed |
| US-20180015077-A1 | COMPOUNDS AND METHODS FOR TREATING HIV INFECTION | NAKAMURA, ROBERT | 2018-01-18 | — | — | US | disclosed |
| EP-3181568-A1 | THIENOPYRIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | Siga Technologies, Inc. (US) | 2017-06-21 | — | — | EP | disclosed |
| EP-3181568-A1 | THIENOPYRIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | Siga Technologies, Inc. (US) | 2017-06-21 | — | — | EP | disclosed |
| US-20170121344-A1 | THIENOPYRIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | SIGA TECHNOLOGIES, INC. (US) | 2017-05-04 | — | — | US | disclosed |
| US-20170121344-A1 | THIENOPYRIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | SIGA TECHNOLOGIES, INC. (US) | 2017-05-04 | — | — | US | disclosed |
| US-20170121344-A1 | THIENOPYRIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | SIGA TECHNOLOGIES, INC. (US) | 2017-05-04 | — | — | US | disclosed |
| EP-2400845-B1 | THIENOPYRIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | SIGA TECH INC (US) | 2017-02-22 | — | — | EP | disclosed |
| US-20110034457-A1 | Pyridothiophene Compounds | VERNALIS (CAMBRIDGE) LIMITED. (GB) | 2011-02-10 | — | — | US | disclosed |
| US-20110034457-A1 | Pyridothiophene Compounds | VERNALIS (CAMBRIDGE) LIMITED. (GB) | 2011-02-10 | — | — | US | disclosed |
| US-20090054452-A1 | Thienopyridine Derivatives and the Use Thereof as Hsp90 Modulators | MERCK PATENT GMBH (DE) | 2009-02-26 | — | — | US | disclosed |
| US-20090054452-A1 | Thienopyridine Derivatives and the Use Thereof as Hsp90 Modulators | MERCK PATENT GMBH (DE) | 2009-02-26 | — | — | US | disclosed |
| US-20090054452-A1 | Thienopyridine Derivatives and the Use Thereof as Hsp90 Modulators | MERCK PATENT GMBH (DE) | 2009-02-26 | — | — | US | disclosed |
| EP-1853609-A1 | THIENOPYRIDINE DERIVATIVES AND USE THEREOF AS HSP90 MODULATORS | Merck Patent GmbH (DE) | 2007-11-14 | — | — | EP | disclosed |
| US-20070213328-A1 | Pyridothiophene Compounds | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2007-09-13 | — | — | US | disclosed |
| US-20070213328-A1 | Pyridothiophene Compounds | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2007-09-13 | — | — | US | disclosed |
| WO-2006092202-A1 | THIENOPYRIDINE DERIVATIVES AND USE THEREOF AS HSP90 MODULATORS | MERCK PATENT GMBH (DE) | 2006-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213328-A1 | Pyridothiophene Compounds | ALK, HSP90AB1, HSP90AA1 | BRAF 246/4885HSP90AB1 2/4885MEN1 3417/4885 |
| US-20090054452-A1 | Thienopyridine Derivatives and the Use Thereof as Hsp90 Modulators | HSP90AA1, HSP90AB1, HSP90AB2P | BRAF 1646/4885HSP90AB1 2/4885MEN1 4561/4885 |
| US-20170121344-A1 | THIENOPYRIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | TTPA, TPMT, SLC19A2 | BRAF 2427/4885HSP90AB1 885/4885MEN1 3532/4885 |
| US-20110034457-A1 | Pyridothiophene Compounds | ALK, HSP90AB1, HSP90AA1 | BRAF 240/4885HSP90AB1 2/4885MEN1 3418/4885 |
| US-20180015077-A1 | COMPOUNDS AND METHODS FOR TREATING HIV INFECTION | CD4, CCR5, MMP8 | BRAF 4247/4885HSP90AB1 1407/4885MEN1 4643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.