Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.84 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 3/20 | 0.44 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL429588 | 0.92 | BRAF (1.00) | BRAFHSP90AB1MEN1KMT2AALDH1A1 | |
| SCHEMBL1776871 | 0.88 | BRAF (0.79) | BRAFHSP90AB1MEN1KMT2AALDH1A1 | |
| SCHEMBL2287561 | 0.88 | BRAF (0.89) | BRAFHSP90AB1MEN1KMT2AALDH1A1 | |
| SCHEMBL1777095 | 0.87 | BRAF (0.77) | BRAFHSP90AB1MEN1KMT2AALDH1A1 | |
| SCHEMBL18537731 | 0.87 | BRAF (0.87) | BRAFHSP90AB1MEN1KMT2AALDH1A1 | |
| SCHEMBL1774806 | 0.87 | BRAF (0.87) | BRAFHSP90AB1MEN1KMT2AALDH1A1 | |
| SCHEMBL1777647 | 0.87 | BRAF (0.76) | BRAFHSP90AB1MEN1KMT2AALDH1A1 | |
| SCHEMBL12377464 | 0.86 | BRAF (0.85) | BRAFHSP90AB1MEN1KMT2AALDH1A1 | |
| SCHEMBL4491329 | 0.86 | BRAF (0.75) | BRAFHSP90AB1MEN1KMT2AALDH1A1 | |
| SCHEMBL12600475 | 0.86 | BRAF (0.75) | BRAFHSP90AB1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943637-B2 | Thienopyridine derivatives and the use thereof as HSP90 modulators | MERCK PATENT GMBH (DE) | 2011-05-17 | — | — | US | disclosed |
| US-7943637-B2 | Thienopyridine derivatives and the use thereof as HSP90 modulators | MERCK PATENT GMBH (DE) | 2011-05-17 | — | — | US | disclosed |
| US-20090054452-A1 | Thienopyridine Derivatives and the Use Thereof as Hsp90 Modulators | MERCK PATENT GMBH (DE) | 2009-02-26 | — | — | US | disclosed |
| US-20090054452-A1 | Thienopyridine Derivatives and the Use Thereof as Hsp90 Modulators | MERCK PATENT GMBH (DE) | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054452-A1 | Thienopyridine Derivatives and the Use Thereof as Hsp90 Modulators | HSP90AA1, HSP90AB1, HSP90AB2P | BRAF 1646/4885HSP90AB1 2/4885MEN1 4561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.