⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13394283 | 0.83 | KDM4E (0.38) | — | |
| SCHEMBL16265080 | 0.75 | — | — | |
| SCHEMBL9771759 | 0.70 | PLA2G7 (0.33) | — | |
| SCHEMBL9771860 | 0.69 | KAT7 (0.31) | — | |
| SCHEMBL10192735 | 0.69 | — | — | |
| SCHEMBL9771886 | 0.68 | LTA4H (0.35) | — | |
| SCHEMBL9771775 | 0.68 | CHRM5 (0.40) | — | |
| SCHEMBL9771822 | 0.68 | — | — | |
| SCHEMBL9771771 | 0.67 | BRD4 (0.38) | — | |
| SCHEMBL13714537 | 0.64 | CNR2 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024059665-A1 | DIMERIC COMPOUNDS AS INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF | MAZE THERAPEUTICS, INC. (US) | 2024-03-21 | — | — | WO | disclosed |
| WO-2022198196-A1 | INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF | MAZE THERAPEUTICS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |
| US-7998954-B2 | Pyrimidodiazepinone derivative | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2011-08-16 | — | — | US | disclosed |