Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12377347 | 1.00 | CCNE1 (0.33) | CCNE1CDK2CDK5FFAR2MDM2 | |
| SCHEMBL14145695 | 0.90 | CCNE1 (0.34) | CCNE1CDK2CDK5MDM2 | |
| SCHEMBL14145694 | 0.90 | CCNE1 (0.34) | CCNE1CDK2CDK5MDM2 | |
| SCHEMBL1691012 | 0.89 | LCK (0.35) | CCNE1CDK2CDK5FFAR2MDM2 | |
| SCHEMBL1691316 | 0.89 | LCK (0.35) | CCNE1CDK2CDK5FFAR2MDM2 | |
| SCHEMBL1926160 | 0.89 | LCK (0.35) | CCNE1CDK2CDK5FFAR2MDM2 | |
| SCHEMBL10124744 | 0.89 | LCK (0.35) | CCNE1CDK2CDK5FFAR2MDM2 | |
| SCHEMBL10125058 | 0.89 | LCK (0.35) | CCNE1CDK2CDK5FFAR2MDM2 | |
| SCHEMBL16681690 | 0.89 | LCK (0.35) | CCNE1CDK2CDK5FFAR2MDM2 | |
| SCHEMBL12377971 | 0.88 | FFAR2 (0.35) | CCNE1CDK2CDK5FFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999113-B2 | Such as 1-(benzo[d][1,3]dioxol-6-yl)-n-(5-((2-chlorophenyl)(3-hydroxypyrrolidin-1-yl)methyl)thiazol-2-yl)cyclopropanecarboxamide; genetic disorders | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-08-16 | — | — | US | disclosed |