Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 9/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.32 |
| ▸ | CYP3A5 | P20815 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PYGL | P06737 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1923732 | 0.89 | S1PR3 (0.39) | FFAR2CCNE1CDK2CDK5CYP3A4 | |
| SCHEMBL1690967 | 0.89 | S1PR3 (0.39) | FFAR2CCNE1CDK2CDK5CYP3A4 | |
| SCHEMBL10125038 | 0.89 | S1PR3 (0.39) | FFAR2CCNE1CDK2CDK5CYP3A4 | |
| SCHEMBL1924081 | 0.89 | S1PR3 (0.39) | FFAR2CCNE1CDK2CDK5CYP3A4 | |
| SCHEMBL1690804 | 0.89 | S1PR3 (0.39) | FFAR2CCNE1CDK2CDK5CYP3A4 | |
| SCHEMBL12377970 | 0.88 | CCNE1 (0.33) | FFAR2CCNE1CDK2CDK5 | |
| SCHEMBL12377347 | 0.88 | CCNE1 (0.33) | FFAR2CCNE1CDK2CDK5 | |
| SCHEMBL16678081 | 0.87 | FFAR2 (0.38) | FFAR2CCNE1CDK2CDK5MAPT | |
| SCHEMBL4765079 | 0.85 | SMN1; SMN2 (0.41) | FFAR2 | |
| SCHEMBL14145310 | 0.83 | S1PR3 (0.37) | FFAR2CCNE1CDK2CDK5CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999113-B2 | Such as 1-(benzo[d][1,3]dioxol-6-yl)-n-(5-((2-chlorophenyl)(3-hydroxypyrrolidin-1-yl)methyl)thiazol-2-yl)cyclopropanecarboxamide; genetic disorders | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-08-16 | — | — | US | disclosed |