Sugi Predict

Sugi Predict / Compounds / SCHEMBL12380495

SCHEMBL12380495

SCHEMBL12380495

COC(=O)c1c(Cl)cc(Cl)nc1C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 5/20 0.44
▸ KMT2A Q03164 4/20 0.44
▸ MEN1 O00255 1/20 0.44
▸ PLA2G2A P14555 2/20 0.43
▸ SMN1; SMN2 Q16637 3/20 0.42
▸ CYP3A4 P08684 2/20 0.41
▸ ACHE P22303 1/20 0.41
▸ LMNA P02545 3/20 0.40
▸ MAPT P10636 2/20 0.40
▸ TSHR P16473 2/20 0.40
▸ HTT P42858 2/20 0.40
▸ GLA P06280 1/20 0.40
▸ HSD17B10 Q99714 1/20 0.40
▸ NPC1 O15118 1/20 0.40
▸ NFKB1 P19838 1/20 0.40
▸ RAB9A P51151 1/20 0.40
▸ NFKB2 Q00653 1/20 0.40
▸ RELA Q04206 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ ALDH1A1 P00352 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25151051 0.87 CYP3A4 (0.47) KDM4EKMT2AMEN1PLA2G2ASMN1; SMN2
SCHEMBL31369008 0.85 KMT2A (0.50) KDM4EKMT2AMEN1PLA2G2ASMN1; SMN2
SCHEMBL1710208 0.85 KDM4E (0.44) KDM4EKMT2AMEN1SMN1; SMN2CYP3A4
SCHEMBL612669 0.84 GAA (0.49) KDM4ESMN1; SMN2LMNAMAPTHTT
SCHEMBL25328907 0.84 ALDH1A1 (0.42) KDM4EKMT2AMEN1PLA2G2ASMN1; SMN2
SCHEMBL30592218 0.84 GAA (0.49) KDM4ESMN1; SMN2LMNAMAPTHTT
SCHEMBL25289195 0.83 CNR1 (0.39) KMT2ASMN1; SMN2LMNAMAPTALDH1A1
SCHEMBL24497609 0.83 S1PR2 (0.37) KDM4EKMT2AMEN1SMN1; SMN2LMNA
SCHEMBL30496268 0.83 CNR1 (0.39) KMT2ASMN1; SMN2LMNAMAPTALDH1A1
SCHEMBL1330555 0.83 ALDH1A1 (0.44) KDM4EKMT2AMEN1SMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023119233-A1 DEUBIQUITINASE INHIBITORS AND METHODS OF USE THEREOF MOLECURE S.A. (PL) 2023-06-29 — — WO disclosed
US-20230133667-A1 MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS RQX PHARMACEUTICALS INC (US) 2023-05-04 — — US disclosed
US-20230133667-A1 MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS RQX PHARMACEUTICALS INC (US) 2023-05-04 — — US disclosed
EP-4019518-A1 TYK2 INHIBITORS AND USES THEREOF Nimbus Lakshmi, Inc. (US) 2022-06-29 — — EP disclosed
EP-3110820-B1 TYK2 INHIBITORS AND USES THEREOF NIMBUS LAKSHMI INC (US) 2022-04-06 — — EP disclosed
US-20210238198-A1 TYK2 INHIBITORS AND USES THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2021-08-05 — — US disclosed
US-20210198316-A9 MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED (GB) 2021-07-01 — — US disclosed
US-10968236-B2 TYK2 inhibitors and uses thereof NIMBUS LAKSHMI, INC. (US) 2021-04-06 — — US disclosed
US-20190248810-A1 TYK2 INHIBITORS AND USES THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2019-08-15 — — US disclosed
US-10253046-B2 TYK2 inhibitors and uses thereof Nimbus Lakshmi (US) 2019-04-09 — — US disclosed
US-9340540-B2 TYK2 inhibitors and uses thereof NIMBUS LAKSHMI, INC. (US) 2016-05-17 — — US disclosed
US-9340540-B2 TYK2 inhibitors and uses thereof NIMBUS LAKSHMI, INC. (US) 2016-05-17 — — US disclosed
US-20150266875-A1 TYK2 INHIBITORS AND USES THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-09-24 — — US disclosed
US-20150266875-A1 TYK2 INHIBITORS AND USES THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-09-24 — — US disclosed
WO-2015131080-A1 TYK2 INHIBITORS AND USES THEREOF NIMBUS LAKSHMI, INC. (US) 2015-09-03 — — WO disclosed
US-8309554-B2 Hypoxia activated drugs of nitrogen mustard alkylators THRESHOLD PHARMACEUTICALS (US) 2012-11-13 — — US disclosed
US-8309554-B2 Hypoxia activated drugs of nitrogen mustard alkylators THRESHOLD PHARMACEUTICALS (US) 2012-11-13 — — US disclosed
US-20110190310-A1 Hypoxia Activated Drugs Of Nitrogen Mustard Alkylators THRESHOLD PHARMACEUTICALS, INC. 2011-08-04 — — US disclosed
US-20110190310-A1 Hypoxia Activated Drugs Of Nitrogen Mustard Alkylators THRESHOLD PHARMACEUTICALS, INC. 2011-08-04 — — US disclosed
WO-2009140553-A2 HYPOXIA ACTIVATED DRUGS OF NITROGEN MUSTARD ALKYLATORS THRESHOLD PHARMACEUTICALS, INC. (US) 2009-11-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110190310-A1 Hypoxia Activated Drugs Of Nitrogen Mustard Alkylators HIF1AN, HIF1A, HYOU1 KDM4E 1577/4885KMT2A 946/4885MEN1 3402/4885
US-20210238198-A1 TYK2 INHIBITORS AND USES THEREOF TYK2, JAK2, JAK1 KDM4E 391/4885KMT2A 206/4885MEN1 2491/4885
US-10968236-B2 TYK2 inhibitors and uses thereof TYK2, JAK2, JAK1 KDM4E 391/4885KMT2A 206/4885MEN1 2491/4885
US-20150266875-A1 TYK2 INHIBITORS AND USES THEREOF TYK2, JAK2, JAK1 KDM4E 391/4885KMT2A 206/4885MEN1 2491/4885
US-20210198316-A9 MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS MRPL21, PEPD, CTSC KDM4E 1763/4885KMT2A 3283/4885MEN1 2531/4885
US-20230133667-A1 MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS MRPL21, PEPD, CTSC KDM4E 1763/4885KMT2A 3283/4885MEN1 2531/4885
US-10253046-B2 TYK2 inhibitors and uses thereof TYK2, JAK2, JAK1 KDM4E 391/4885KMT2A 206/4885MEN1 2491/4885
US-20190248810-A1 TYK2 INHIBITORS AND USES THEREOF TYK2, JAK2, JAK1 KDM4E 391/4885KMT2A 206/4885MEN1 2491/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.