Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 13/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 2/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | PRKCG | P05129 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | TYK2 | P29597 | 2/20 | 0.34 |
| ▸ | CLK2 | P49760 | 2/20 | 0.34 |
| ▸ | GSK3A | P49840 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2300557 | 0.92 | MET (0.53) | METRPS6KA3PLK4AURKAMAPK13 | |
| SCHEMBL12386167 | 0.89 | MET (0.59) | METRPS6KA3PLK4AURKAMAPK13 | |
| SCHEMBL12386151 | 0.87 | MET (0.49) | METRPS6KA3GABRA1TMEM97MAPK1 | |
| SCHEMBL12386165 | 0.84 | MET (0.46) | METRPS6KA3GABRA1TMEM97KDM4E | |
| SCHEMBL12386156 | 0.82 | MET (0.46) | METRPS6KA3PLK4AURKAMAPK13 | |
| SCHEMBL12386134 | 0.81 | GABRA1 (0.38) | METRPS6KA3GABRA1TMEM97KDM4E | |
| SCHEMBL12386159 | 0.81 | MET (0.44) | METRPS6KA3KDM4EALDH1A1MAPT | |
| SCHEMBL12386157 | 0.81 | MET (0.49) | METRPS6KA3GABRA1TMEM97KDM4E | |
| SCHEMBL1414986 | 0.80 | MET (0.66) | METRPS6KA3PLK4AURKAMAPK13 | |
| SCHEMBL9906884 | 0.80 | MET (0.48) | METRPS6KA3MAPK1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8551989-B2 | Substituted 4-(indazolyl)-1,4-dihydropyridines and methods of use thereof | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-10-08 | — | — | US | disclosed |
| US-20110207731-A1 | SUBSTITUTED 4-(INDAZOLYL)-1,4-DIHYDROPYRIDINES AND METHODS OF USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207731-A1 | SUBSTITUTED 4-(INDAZOLYL)-1,4-DIHYDROPYRIDINES AND METHODS OF USE THEREOF | MET, ERBB4, RET | MET 1/4885RPS6KA3 752/4885PLK4 1205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.