Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.50 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 6/20 | 0.39 |
| ▸ | GLA | P06280 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | PDE9A | O76083 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12389545 | 0.89 | RXRA (0.53) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL4899614 | 0.87 | NR1H2 (0.52) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL12390329 | 0.86 | RXRA (0.58) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL12390445 | 0.85 | RXRA (0.57) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL14944219 | 0.84 | RXRA (0.55) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL12366985 | 0.83 | RXRA (0.35) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL2263602 | 0.82 | RXRA (0.52) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL4907677 | 0.81 | RXRA (0.49) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL2386420 | 0.80 | RXRA (0.67) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL2265833 | 0.80 | KDM4E (0.55) | RXRANR1H2NR1H3ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |