Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.55 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.55 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | PDE9A | O76083 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12390329 | 0.93 | RXRA (0.58) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL12390445 | 0.93 | RXRA (0.57) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL2265070 | 0.90 | KDM4E (0.50) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL12389545 | 0.86 | RXRA (0.53) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL2386386 | 0.84 | RXRA (0.59) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL2388657 | 0.84 | RXRA (0.72) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL12390331 | 0.84 | RXRA (0.50) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL2388590 | 0.83 | NR1H2 (0.62) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL2264949 | 0.82 | RXRA (0.47) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL2265833 | 0.82 | KDM4E (0.55) | RXRANR1H2NR1H3ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465869-B1 | MODULATORS OF LXR | EXELIXIS PATENT CO LLC (US) | 2013-05-15 | — | — | EP | disclosed |