Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 11/20 | 0.86 |
| ▸ | PGR | P06401 | 6/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.86 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.86 |
| ▸ | LMNA | P02545 | 2/20 | 0.86 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.86 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.86 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.86 |
| ▸ | IL5 | P05113 | 1/20 | 0.86 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.86 |
| ▸ | AR | P10275 | 1/20 | 0.86 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.86 |
| ▸ | MMP9 | P14780 | 1/20 | 0.86 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.86 |
| ▸ | THPO | P40225 | 1/20 | 0.86 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.86 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.86 |
| ▸ | BLM | P54132 | 1/20 | 0.86 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.86 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7741860 | 1.00 | NR3C1 (0.86) | NR3C1PGRCYP3A4HIF1ALMNA | |
| SCHEMBL12465053 | 1.00 | NR3C1 (0.86) | NR3C1PGRCYP3A4HIF1ALMNA | |
| SCHEMBL30376033 | 0.94 | NR3C1 (0.83) | NR3C1PGRCYP3A4HIF1ALMNA | |
| SCHEMBL7905859 | 0.94 | NR3C1 (0.82) | NR3C1PGRCYP3A4HIF1ALMNA | |
| SCHEMBL20149287 | 0.94 | NR3C1 (0.85) | NR3C1PGRCYP3A4HIF1ALMNA | |
| SCHEMBL20370199 | 0.94 | NR3C1 (0.89) | NR3C1PGRCYP3A4HIF1ALMNA | |
| SCHEMBL20223507 | 0.94 | NR3C1 (0.89) | NR3C1PGRCYP3A4HIF1ALMNA | |
| Budesonide SCHEMBL4448854 | 0.93 | NR3C1 (0.97) | NR3C1PGRCYP3A4HIF1ALMNA | |
| Budesonide SCHEMBL13871728 | 0.93 | NR3C1 (1.00) | NR3C1PGRCYP3A4HIF1ALMNA | |
| Budesonide SCHEMBL1130417 | 0.93 | NR3C1 (1.00) | NR3C1PGRCYP3A4HIF1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8524697-B2 | C20-C21 substituted glucocorticoid receptor agonists | MERCK SHARP & DOHME CORP. (US) | 2013-09-03 | — | — | US | disclosed |
| US-8524697-B2 | C20-C21 substituted glucocorticoid receptor agonists | MERCK SHARP & DOHME CORP. (US) | 2013-09-03 | — | — | US | disclosed |
| US-20110182828-A1 | C20-C21 SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS | SCHERING CORPORATION (US) | 2011-07-28 | — | — | US | disclosed |
| US-20110182828-A1 | C20-C21 SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS | SCHERING CORPORATION (US) | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110182828-A1 | C20-C21 SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS | NR3C1, MC2R, NR3C2 | NR3C1 1/4885PGR 318/4885CYP3A4 342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.