Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 8/20 | 0.42 |
| ▸ | CLK3 | P49761 | 8/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.42 |
| ▸ | WNT1 | P04628 | 7/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12396270 | 0.91 | CLK2 (0.41) | CLK2CLK3DYRK1AWNT1CCNT1 | |
| SCHEMBL12396644 | 0.90 | CLK2 (0.41) | CLK2CLK3DYRK1AWNT1CCNT1 | |
| SCHEMBL12397393 | 0.90 | CLK2 (0.40) | CLK2CLK3DYRK1AWNT1CCNT1 | |
| SCHEMBL12396291 | 0.88 | PARP1 (0.59) | PARP1DHODHCLK2CLK3DYRK1A | |
| SCHEMBL12370040 | 0.88 | CLK2 (0.53) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL12395513 | 0.88 | CLK2 (0.41) | CLK2CLK3DYRK1AWNT1CCNT1 | |
| SCHEMBL12396267 | 0.87 | WNT1 (0.44) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL12395397 | 0.87 | CLK2 (0.50) | PARP1DHODHCLK2CLK3DYRK1A | |
| SCHEMBL20041256 | 0.87 | CLK2 (0.42) | CLK2CLK3DYRK1AWNT1CCNT1 | |
| SCHEMBL12395407 | 0.86 | WNT1 (0.47) | CLK2CLK3DYRK1AWNT1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170202846-A1 | 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | VICKERS VENTURE FUND VI PTE. LTD. (SG) | 2017-07-20 | — | — | US | disclosed |
| US-9446035-B2 | 1H-pyrazolo[3,4-b]pyridines and therapeutic uses thereof | SAMUMED, LLC (US) | 2016-09-20 | — | — | US | disclosed |
| US-20160101092-A1 | 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | VICKERS VENTURE FUND VI (PLAN) PTE. LTD. (SG) | 2016-04-14 | — | — | US | disclosed |
| US-20160101092-A1 | 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | VICKERS VENTURE FUND VI (PLAN) PTE. LTD. (SG) | 2016-04-14 | — | — | US | disclosed |
| US-9067939-B2 | 1H-pyrazolo[3,4-b]pyridines and therapeutic uses thereof | SAMUMED, LLC (US) | 2015-06-30 | — | — | US | disclosed |
| US-20150045360-A1 | 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | VICKERS VENTURE FUND VI (PLAN) PTE. LTD. (SG) | 2015-02-12 | — | — | US | disclosed |
| US-8901150-B2 | 1H-pyrazolo[3,4-B]pyridines and therapeutic uses thereof | SAMUMED, LLC (US) | 2014-12-02 | — | — | US | disclosed |
| US-20140323479-A1 | 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | VICKERS-SPLICE CO-INVESTMENT LLC (KY) | 2014-10-30 | — | — | US | disclosed |
| US-8846714-B2 | 1H-pyrazolo[3,4-β]pyridines and therapeutic uses thereof | SAMUMED, LLC (US) | 2014-09-30 | — | — | US | disclosed |
| US-8815897-B2 | 1H-pyrazolo[3,4-B]pyridines and therapeutic uses thereof | SAMUMED, LLC (US) | 2014-08-26 | — | — | US | disclosed |
| US-20130296307-A1 | 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | VICKERS VENTURE FUND VI PTE. LTD. (SG) | 2013-11-07 | — | — | US | disclosed |
| US-20130225576-A1 | 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | SAMUMED, LLC (US) | 2013-08-29 | — | — | US | disclosed |
| US-8450340-B2 | 1H-pyrazolo[3,4-b]pyridines and therapeutic uses thereof | SAMUMED, LLC (US) | 2013-05-28 | — | — | US | disclosed |
| US-20110190290-A1 | 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | EPITHERIX, LLC (US) | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190290-A1 | 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | BRCA1, THPO, PDXK | PARP1 74/4885DHODH 905/4885CLK2 2380/4885 |
| US-20130225576-A1 | 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | BRCA1, THPO, PDXK | PARP1 74/4885DHODH 905/4885CLK2 2380/4885 |
| US-20150045360-A1 | 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | BRCA1, THPO, PDXK | PARP1 74/4885DHODH 905/4885CLK2 2380/4885 |
| US-20140323479-A1 | 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | BRCA1, THPO, PDXK | PARP1 74/4885DHODH 905/4885CLK2 2380/4885 |
| US-20160101092-A1 | 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | BRCA1, THPO, PDXK | PARP1 74/4885DHODH 905/4885CLK2 2380/4885 |
| US-20170202846-A1 | 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | BRCA1, THPO, PDXK | PARP1 74/4885DHODH 905/4885CLK2 2380/4885 |
| US-20130296307-A1 | 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | BRCA1, THPO, PDXK | PARP1 74/4885DHODH 905/4885CLK2 2380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.