Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 5/20 | 0.69 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | MC4R | P32245 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13743029 | 0.85 | KMT2A (0.79) | PTGS1PTGS2KMT2AABCB11ALDH1A1 | |
| SCHEMBL6294549 | 0.84 | PTGS1 (0.73) | PTGS1PTGS2KMT2A | |
| SCHEMBL5698483 | 0.84 | PTGS1 (0.73) | PTGS1PTGS2KMT2A | |
| SCHEMBL1557809 | 0.84 | PTGS2 (0.62) | PTGS1PTGS2KMT2AABCB11ALDH1A1 | |
| SCHEMBL12404411 | 0.79 | PTGS1 (0.76) | PTGS1PTGS2KMT2AALDH1A1 | |
| SCHEMBL13524329 | 0.78 | PTGS2 (1.00) | PTGS1PTGS2ABCB11ALDH1A1MT-CO2 | |
| SCHEMBL7951909 | 0.78 | CYP2D6 (0.60) | PTGS1KMT2AALDH1A1 | |
| SCHEMBL22246047 | 0.75 | KMT2A (0.49) | PTGS1PTGS2KMT2AABCB11ALDH1A1 | |
| SCHEMBL13317734 | 0.75 | PTGS1 (0.71) | PTGS1PTGS2KMT2A | |
| SCHEMBL13742879 | 0.74 | PTGS1 (0.68) | PTGS1PTGS2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150344467-A1 | 5- AND 6-MEMBERED HETEROCYCLIC COMPOUNDS | FMR LLC | 2015-12-03 | — | — | US | disclosed |
| US-20140038965-A1 | 5- AND 6-MEMBERED HETEROCYCLIC COMPOUNDS | ENVIVO PHARMACEUTICALS, INC. (US) | 2014-02-06 | — | — | US | disclosed |
| US-8481534-B2 | 5- and 6-membered heterocyclic compounds | ENVIVO PHARMACEUTICALS, INC. (US) | 2013-07-09 | — | — | US | disclosed |
| US-20110183976-A1 | 5- AND 6-MEMBERED HETEROCYCLIC COMPOUNDS | FMR LLC | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150344467-A1 | 5- AND 6-MEMBERED HETEROCYCLIC COMPOUNDS | PDE7A, ACHE, PDE5A | PTGS1 1136/4885PTGS2 1776/4885KMT2A 2855/4885 |
| US-20140038965-A1 | 5- AND 6-MEMBERED HETEROCYCLIC COMPOUNDS | PDE7A, ACHE, PDE5A | PTGS1 1136/4885PTGS2 1776/4885KMT2A 2855/4885 |
| US-20110183976-A1 | 5- AND 6-MEMBERED HETEROCYCLIC COMPOUNDS | ACHE, PDE7A, PDE5A | PTGS1 1042/4885PTGS2 1757/4885KMT2A 2900/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.