SCHEMBL12406783

SCHEMBL12406783

COc1ccc(CO[C@@H]2[C@@H](OCc3ccc(OC)cc3)[C@H](OCCCO)O[C@H](COS(=O)(=O)c3ccc(C)cc3)[C@H]2OCc2ccc(OC)cc2)cc1

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ FGF1 P05230 3/20 0.37
▸ FGF2 P09038 3/20 0.37
▸ VEGFA P15692 3/20 0.37
▸ HPSE Q9Y251 3/20 0.37
▸ SSTR1 P30872 1/20 0.36
▸ SSTR2 P30874 1/20 0.36
▸ SSTR4 P31391 1/20 0.36
▸ SSTR3 P32745 1/20 0.36
▸ SSTR5 P35346 1/20 0.36
▸ GJB2 P29033 1/20 0.36
▸ GJA1 P17302 1/20 0.36
▸ BCHE P06276 1/20 0.35
▸ ACHE P22303 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ EGFR P00533 1/20 0.35
▸ FKBP1A P62942 1/20 0.35
▸ CA1 P00915 1/20 0.35
▸ CA2 P00918 1/20 0.35
▸ CA9 Q16790 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12406827 0.91 FGF1 (0.36) FGF1FGF2VEGFAHPSEGJB2
SCHEMBL13057269 0.90 SSTR1 (0.44) FGF1FGF2VEGFAHPSESSTR1
SCHEMBL2172388 0.90 SSTR1 (0.44) FGF1FGF2VEGFAHPSESSTR1
SCHEMBL2172392 0.90 SSTR1 (0.44) FGF1FGF2VEGFAHPSESSTR1
SCHEMBL13272797 0.87 HPSE (0.41) FGF1FGF2VEGFAHPSECA1
SCHEMBL12479738 0.87 HPSE (0.41) FGF1FGF2VEGFAHPSECA1
SCHEMBL12406775 0.85 BCHE (0.36) FGF1FGF2VEGFAHPSESSTR1
SCHEMBL13057285 0.83 ALDH1A1 (0.38) BCHEACHEALDH1A1EGFRFKBP1A
SCHEMBL13224946 0.83 TACR1 (0.41) FGF1FGF2VEGFAHPSESSTR1
SCHEMBL13057315 0.81 FGF1 (0.42) FGF1FGF2VEGFAHPSESSTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7973145-B2 Sulfonated sugar compounds, pharmaceutical compositions which contain the same, and methods of treating tumors with the same TOYO SUISAN KAISHA, LTD. (JP) 2011-07-05 — — US disclosed
US-20090209475-A1 Sulfonated sugar compounds, pharmaceutical compositions which contain the same, and methods of treating tumors with the same TOYO SUISAN KAISHA, LTD. (JP) 2009-08-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090209475-A1 Sulfonated sugar compounds, pharmaceutical compositions which contain the same, and methods of treating tumors with the same SLC5A2, SLC5A1, DEGS1 FGF1 1431/4885FGF2 955/4885VEGFA 4475/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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