Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.53 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.53 |
| ▸ | AXL | P30530 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 5/20 | 0.44 |
| ▸ | JAK3 | P52333 | 5/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30676600 | 0.86 | AXL (0.63) | AXLJAK2JAK3OPRK1NR4A2 | |
| SCHEMBL1427263 | 0.86 | AXL (0.63) | AXLJAK2JAK3OPRK1NR4A2 | |
| SCHEMBL8321080 | 0.84 | PDPK1 (0.42) | GABRA1GABRB1GABRA3GABRB2AXL | |
| SCHEMBL8313411 | 0.84 | PDPK1 (0.42) | GABRA1GABRB1GABRA3GABRB2AXL | |
| SCHEMBL7968762 | 0.84 | AXL (0.48) | GABRA1GABRB2AXLMEN1KMT2A | |
| SCHEMBL8478533 | 0.82 | PLK4 (0.44) | GABRA1GABRB1GABRA3GABRB2AXL | |
| SCHEMBL1516568 | 0.80 | DYRK1A (0.48) | AXLJAK2JAK3OPRK1NR4A2 | |
| SCHEMBL7971778 | 0.80 | AXL (0.56) | AXLMEN1KMT2ANUDT1JAK2 | |
| SCHEMBL4828101 | 0.79 | AURKA (0.54) | AXLJAK2JAK3NR4A2 | |
| SCHEMBL28046056 | 0.79 | BRAF (0.53) | AXLJAK2JAK3NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8466170-B2 | 7-azaindole derivatives | MERCK PATENT GMBH (DE) | 2013-06-18 | — | — | US | disclosed |
| US-8466170-B2 | 7-azaindole derivatives | MERCK PATENT GMBH (DE) | 2013-06-18 | — | — | US | disclosed |
| US-20110166175-A1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-07-07 | — | — | US | disclosed |
| US-20110166175-A1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166175-A1 | 7-AZAINDOLE DERIVATIVES | JAK3, AZI2, MYLK2 | GABRA1 3155/4885GABRB1 3145/4885GABRA3 2573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.