Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 10/20 | 0.44 |
| ▸ | JAK3 | P52333 | 10/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12829916 | 0.84 | AXL (0.37) | AXLMEN1KMT2ANUDT1JAK2 | |
| SCHEMBL12409372 | 0.84 | GABRA1 (0.53) | AXLMEN1KMT2ANUDT1JAK2 | |
| SCHEMBL12657427 | 0.80 | PIK3CA (0.46) | AXL | |
| SCHEMBL7971778 | 0.80 | AXL (0.56) | AXLMEN1KMT2ANUDT1JAK2 | |
| SCHEMBL14002174 | 0.76 | BTK (0.42) | AXLCYP3A4CYP2C19 | |
| SCHEMBL8469861 | 0.76 | AXL (0.39) | AXL | |
| SCHEMBL8443770 | 0.76 | BTK (0.40) | MEN1KMT2ACYP3A4 | |
| SCHEMBL20780788 | 0.75 | KDM4E (0.49) | MEN1KMT2AALDH1A1 | |
| SCHEMBL7956049 | 0.75 | MAP2K1 (0.74) | MEN1KMT2ANUDT1JAK2JAK3 | |
| SCHEMBL21701301 | 0.74 | JAK3 (0.46) | AXLMEN1KMT2ANUDT1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010020308-A1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-02-25 | — | — | WO | disclosed |