⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27663102 | 0.76 | — | — | |
| SCHEMBL11915409 | 0.76 | — | — | |
| SCHEMBL28106415 | 0.74 | — | — | |
| SCHEMBL12723415 | 0.73 | — | — | |
| SCHEMBL6967494 | 0.70 | — | — | |
| SCHEMBL24201428 | 0.69 | SHBG (0.34) | — | |
| SCHEMBL1678406 | 0.69 | — | — | |
| SCHEMBL6962385 | 0.69 | SHBG (0.37) | — | |
| SCHEMBL170904 | 0.68 | SHBG (0.50) | — | |
| SCHEMBL1870619 | 0.68 | SHBG (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372847-B2 | Pyrazinone modulator of corticotropin-releasing factor receptor activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-02-12 | — | — | US | disclosed |
| US-20110166160-A1 | Pyrazinone Modulator of Corticotropin-Releasing Factor Receptor Activity | BRISTOL-MYERS SQUIBB COMPANY | 2011-07-07 | — | — | US | disclosed |