SCHEMBL12410798

SCHEMBL12410798

O=c1[nH]c(=O)n(Cc2ccc(F)c(F)c2)cc1C#CBr

nearest known ligand 0.64

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MMP10 P09238 11/20 0.46
MMP13 P45452 11/20 0.46
DAO P14920 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17243353 0.89 MMP10 (0.48) MMP10MMP13DAO
SCHEMBL12410760 0.85 MEN1 (0.44) MMP10MMP13
SCHEMBL12499618 0.81 MEN1 (0.58) DAO
SCHEMBL17243354 0.80 HPGD (0.54)
SCHEMBL1557266 0.80 HPGD (0.60) MMP10MMP13DAO
SCHEMBL12410816 0.79 MMP13 (0.38) MMP10MMP13DAO
SCHEMBL5126504 0.79 HPGD (0.62)
SCHEMBL12410767 0.78 MMP13 (0.50) MMP10MMP13DAO
SCHEMBL2183455 0.76 DAO (0.42) DAO
SCHEMBL12410801 0.76 DBH (0.43) MMP10MMP13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9181199-B2 Uracil derivatives and use thereof RESPROTECT GMBH (DE) 2015-11-10 US disclosed
US-9181199-B2 Uracil derivatives and use thereof RESPROTECT GMBH (DE) 2015-11-10 US disclosed
US-20110166096-A1 URACIL DERIVATIVES AND USE THEREOF RESPROTECT GMBH (DE) 2011-07-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110166096-A1 URACIL DERIVATIVES AND USE THEREOF TYMP, UNG, DPYD MMP10 4311/4885MMP13 4466/4885DAO 1976/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.