Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.63 |
| ▸ | PDGFRA | P16234 | 16/20 | 0.63 |
| ▸ | KIT | P10721 | 1/20 | 0.61 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.61 |
| ▸ | AXL | P30530 | 1/20 | 0.61 |
| ▸ | MET | P08581 | 2/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12411524 | 0.94 | KDR (0.69) | KDRPDGFRAKITFGFR2AXL | |
| SCHEMBL12410871 | 0.93 | KDR (0.56) | KDRPDGFRAKITFGFR2AXL | |
| SCHEMBL12411518 | 0.92 | PDGFRA (0.67) | KDRPDGFRAKITAXLMET | |
| SCHEMBL12411553 | 0.86 | KDR (0.63) | KDRPDGFRAKITFGFR2AXL | |
| SCHEMBL12410670 | 0.85 | KDR (0.54) | KDRPDGFRAKITFGFR2AXL | |
| SCHEMBL12410868 | 0.85 | KDR (0.58) | KDRPDGFRAKITFGFR2AXL | |
| SCHEMBL12411663 | 0.85 | KDR (0.58) | KDRPDGFRAKITFGFR2AXL | |
| SCHEMBL12411376 | 0.84 | KDR (0.82) | KDRPDGFRAKITFGFR2AXL | |
| SCHEMBL12411657 | 0.84 | KDR (0.59) | KDRPDGFRAKITFGFR2AXL | |
| SCHEMBL12411111 | 0.84 | KDR (0.57) | KDRPDGFRAKITFGFR2AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973160-B2 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-07-05 | — | — | US | disclosed |
| US-20100197911-A1 | Nitrogen-Containing Aromatic Derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-08-05 | — | — | US | disclosed |
| US-7612092-B2 | Urea derivatives containing aromatic or heteroaromatic rings; 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide; prophylactic or therapeutic agent for a disease for which angiogenesis inhibition is effective | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-11-03 | — | — | US | disclosed |
| US-7253286-B2 | Urea derivatives containing aromatic or heteroaromatic rings, useful as prophylactic or therapeutic agent for a disease for which angiogenesis inhibition is effective | EISAI CO., LTD (JP) | 2007-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197911-A1 | Nitrogen-Containing Aromatic Derivatives | GNG2, GCG, FRG1 | KDR 2687/4885PDGFRA 3131/4885KIT 1497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.