Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | GALR3 | O60755 | 2/20 | 0.43 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12412256 | 0.85 | SMN1; SMN2 (0.36) | MKNK1SMN1; SMN2RAB9AHTTNPC1 | |
| SCHEMBL2178061 | 0.84 | TP53 (0.40) | MKNK1SMN1; SMN2RAB9AHTTNPC1 | |
| SCHEMBL12412270 | 0.83 | SMN1; SMN2 (0.58) | MKNK1SMN1; SMN2RAB9AHTTNPC1 | |
| SCHEMBL12412280 | 0.83 | SMN1; SMN2 (0.45) | MKNK1SMN1; SMN2RAB9AHTTNPC1 | |
| SCHEMBL12788566 | 0.80 | MAPT (0.43) | SMN1; SMN2RAB9AHTTNPC1GALR3 | |
| SCHEMBL12412302 | 0.79 | HTT (0.38) | MKNK1SMN1; SMN2RAB9AHTTNPC1 | |
| SCHEMBL2179694 | 0.79 | KDR (0.33) | MKNK1SMN1; SMN2RAB9AHTTNPC1 | |
| SCHEMBL2178121 | 0.77 | SMN1; SMN2 (0.57) | MKNK1SMN1; SMN2RAB9AHTTNPC1 | |
| SCHEMBL2181171 | 0.77 | THRB (0.41) | MKNK1SMN1; SMN2RAB9AHTTNPC1 | |
| SCHEMBL2177710 | 0.76 | SMN1; SMN2 (0.56) | MKNK1SMN1; SMN2RAB9AHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921382-B2 | Thiazolo[5,4-d] pyrimidines and their use as agrochemicals | DOW AGROSCIENCES, LLC. (US) | 2014-12-30 | — | — | US | disclosed |
| US-8921382-B2 | Thiazolo[5,4-d] pyrimidines and their use as agrochemicals | DOW AGROSCIENCES, LLC. (US) | 2014-12-30 | — | — | US | disclosed |
| EP-2521452-B1 | THIAZOLO[5,4-d]PYRIMIDINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2014-12-24 | — | — | EP | disclosed |
| WO-2011085084-A1 | THIAZOLO[5,4-d] PYRIMIDINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2011-07-14 | — | — | WO | disclosed |
| US-20110166164-A1 | THIAZOLO[5,4-d] PYRIMIDINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC | 2011-07-07 | — | — | US | disclosed |
| US-20110166164-A1 | THIAZOLO[5,4-d] PYRIMIDINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166164-A1 | THIAZOLO[5,4-d] PYRIMIDINES AND THEIR USE AS AGROCHEMICALS | DPYD, TYMS, TYMP | MKNK1 3688/4885SMN1; SMN2 2492/4885RAB9A 3424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.