Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 9/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.33 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.33 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | GALR3 | O60755 | 3/20 | 0.33 |
| ▸ | NR2F2 | P24468 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12412254 | 0.85 | MKNK1 (0.44) | SMN1; SMN2HTTRAB9AMKNK1LMNA | |
| SCHEMBL12412302 | 0.85 | HTT (0.38) | SMN1; SMN2HTTRAB9AMKNK1LMNA | |
| SCHEMBL2181622 | 0.82 | HTT (0.43) | SMN1; SMN2HTTRAB9AMKNK1LMNA | |
| SCHEMBL12412278 | 0.81 | SMN1; SMN2 (0.36) | SMN1; SMN2HTTRAB9AMKNK1PI4KA | |
| SCHEMBL12788970 | 0.79 | HTT (0.33) | SMN1; SMN2HTTRAB9ALMNANR2F2 | |
| SCHEMBL2178061 | 0.78 | TP53 (0.40) | SMN1; SMN2HTTRAB9AMKNK1LMNA | |
| SCHEMBL2180549 | 0.75 | HTT (0.39) | SMN1; SMN2HTTRAB9AMKNK1PI4KA | |
| SCHEMBL2178121 | 0.74 | SMN1; SMN2 (0.57) | SMN1; SMN2HTTRAB9AMKNK1LMNA | |
| SCHEMBL2179694 | 0.74 | KDR (0.33) | SMN1; SMN2HTTRAB9AMKNK1LMNA | |
| SCHEMBL2178593 | 0.74 | RAB9A (0.53) | SMN1; SMN2HTTRAB9ALMNAGALR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921382-B2 | Thiazolo[5,4-d] pyrimidines and their use as agrochemicals | DOW AGROSCIENCES, LLC. (US) | 2014-12-30 | — | — | US | disclosed |
| US-8921382-B2 | Thiazolo[5,4-d] pyrimidines and their use as agrochemicals | DOW AGROSCIENCES, LLC. (US) | 2014-12-30 | — | — | US | disclosed |
| EP-2521452-B1 | THIAZOLO[5,4-d]PYRIMIDINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2014-12-24 | — | — | EP | disclosed |
| EP-2521452-B1 | THIAZOLO[5,4-d]PYRIMIDINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2014-12-24 | — | — | EP | disclosed |
| WO-2011085084-A1 | THIAZOLO[5,4-d] PYRIMIDINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC (US) | 2011-07-14 | — | — | WO | disclosed |
| US-20110166164-A1 | THIAZOLO[5,4-d] PYRIMIDINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC | 2011-07-07 | — | — | US | disclosed |
| US-20110166164-A1 | THIAZOLO[5,4-d] PYRIMIDINES AND THEIR USE AS AGROCHEMICALS | DOW AGROSCIENCES LLC | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166164-A1 | THIAZOLO[5,4-d] PYRIMIDINES AND THEIR USE AS AGROCHEMICALS | DPYD, TYMS, TYMP | SMN1; SMN2 2492/4885HTT 1922/4885RAB9A 3424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.