Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | HTR7 | P34969 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MOGAT2 | Q3SYC2 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2400927 | 1.00 | HRH3 (0.46) | HRH3HTR7TSHRALDH1A1MOGAT2 | |
| Water SCHEMBL16161850 | 0.99 | HRH3 (0.46) | HRH3HTR7TSHRALDH1A1MOGAT2 | |
| Oxalic Acid SCHEMBL1241171 | 0.96 | HRH3 (0.44) | HRH3HTR7TSHRALDH1A1MOGAT2 | |
| SCHEMBL5630601 | 0.96 | HTR7 (0.45) | HRH3HTR7TSHRALDH1A1TP53 | |
| Fumaric Acid SCHEMBL9898674 | 0.93 | TSHR (0.41) | HRH3HTR7TSHRALDH1A1MOGAT2 | |
| Fumaric Acid SCHEMBL9898673 | 0.93 | TSHR (0.41) | HRH3HTR7TSHRALDH1A1MOGAT2 | |
| Fumaric Acid SCHEMBL27987046 | 0.93 | TSHR (0.41) | HRH3HTR7TSHRALDH1A1MOGAT2 | |
| Fumaric Acid SCHEMBL9898162 | 0.93 | TSHR (0.41) | HRH3HTR7TSHRALDH1A1MOGAT2 | |
| Fumaric Acid SCHEMBL2435679 | 0.93 | TSHR (0.41) | HRH3HTR7TSHRALDH1A1MOGAT2 | |
| Fumaric Acid SCHEMBL2435682 | 0.93 | TSHR (0.41) | HRH3HTR7TSHRALDH1A1MOGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1956962-B | Tetrahydroisoquinoline sulfonamide derivatives, their preparation and their use in therapy | SANOFI AVENTIS | 2014-08-20 | — | — | CN | claimed |
| EP-1753725-B1 | TETRAHYDROISOQUINOLINE SULFONAMIDE DERIVATIVES, THE PREPARATION THEREOF, AND THE USE OF THE SAME IN THERAPEUTICS | SANOFI SA (FR) | 2013-02-27 | — | — | EP | claimed |
| US-8273733-B2 | Tetrahydroisoquinoline sulfonamide derivatives, the preparation thereof, and the use of the same in therapeutics | SANOFI (FR) | 2012-09-25 | — | — | US | claimed |
| US-20110028475-A1 | TETRAHYDROISOQUINOLINE SULFONAMIDE DERIVATIVES, THE PREPARATION THEREOF, AND THE USE OF THE SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2011-02-03 | — | — | US | claimed |
| US-7833999-B2 | Tetrahydroisoquinoline sulfonamide derivatives, the preparation thereof, and the use of the same in therapeutics | SANOFI-AVENTIS (FR) | 2010-11-16 | — | — | US | claimed |
| US-20070105834-A1 | TETRAHYDROISOQUINOLINE SULFONAMIDE DERIVATIVES, THE PREPARATION THEREOF, AND THE USE OF THE SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2007-05-10 | — | — | US | claimed |
| CN-1956962-A | Tetrahydroisoquinoline sulfonamide derivatives, their preparation and their use in therapy | SANOFI AVENTIS (FR) | 2007-05-02 | — | — | CN | claimed |
| EP-1753725-A1 | TETRAHYDROISOQUINOLINE SULFONAMIDE DERIVATIVES, THE PREPARATION THEREOF, AND THE USE OF THE SAME IN THERAPEUTICS | Sanofi-Aventis (FR) | 2007-02-21 | — | — | EP | claimed |
| WO-2005118547-A1 | TETRAHYDROISOQUINOLINE SULFONAMIDE DERIVATIVES, THE PREPARATION THEREOF, AND THE USE OF THE SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2005-12-15 | — | — | WO | claimed |
| EP-2833887-A1 | AN H3 RECEPTOR ANTAGONIST FOR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE | SANOFI (FR) | 2015-02-11 | — | — | EP | disclosed |
| CN-1956962-B | Tetrahydroisoquinoline sulfonamide derivatives, their preparation and their use in therapy | SANOFI AVENTIS | 2014-08-20 | — | — | CN | disclosed |
| WO-2013150150-A1 | AN H3 RECEPTOR ANTAGONIST FOR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE | SANOFI (FR) | 2013-10-10 | — | — | WO | disclosed |
| US-8524700-B2 | Tetrahydroisoquinoline sulfonamide derivatives, the preparation thereof, and the use of the same in therapeutics | SANOFI (FR) | 2013-09-03 | — | — | US | disclosed |
| US-8524700-B2 | Tetrahydroisoquinoline sulfonamide derivatives, the preparation thereof, and the use of the same in therapeutics | SANOFI (FR) | 2013-09-03 | — | — | US | disclosed |
| US-20070105834-A1 | TETRAHYDROISOQUINOLINE SULFONAMIDE DERIVATIVES, THE PREPARATION THEREOF, AND THE USE OF THE SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2007-05-10 | — | — | US | disclosed |
| US-20070105834-A1 | TETRAHYDROISOQUINOLINE SULFONAMIDE DERIVATIVES, THE PREPARATION THEREOF, AND THE USE OF THE SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2007-05-10 | — | — | US | disclosed |
| US-20070105834-A1 | TETRAHYDROISOQUINOLINE SULFONAMIDE DERIVATIVES, THE PREPARATION THEREOF, AND THE USE OF THE SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2007-05-10 | — | — | US | disclosed |
| CN-1956962-A | Tetrahydroisoquinoline sulfonamide derivatives, their preparation and their use in therapy | SANOFI AVENTIS (FR) | 2007-05-02 | — | — | CN | disclosed |
| EP-1753725-A1 | TETRAHYDROISOQUINOLINE SULFONAMIDE DERIVATIVES, THE PREPARATION THEREOF, AND THE USE OF THE SAME IN THERAPEUTICS | Sanofi-Aventis (FR) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005118547-A1 | TETRAHYDROISOQUINOLINE SULFONAMIDE DERIVATIVES, THE PREPARATION THEREOF, AND THE USE OF THE SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105834-A1 | TETRAHYDROISOQUINOLINE SULFONAMIDE DERIVATIVES, THE PREPARATION THEREOF, AND THE USE OF THE SAME IN THERAPEUTICS | BACE1, SLC6A2, KCNQ2 | HRH3 128/4885HTR7 175/4885TSHR 2053/4885 |
| US-20110028475-A1 | TETRAHYDROISOQUINOLINE SULFONAMIDE DERIVATIVES, THE PREPARATION THEREOF, AND THE USE OF THE SAME IN THERAPEUTICS | BACE1, HTR2B, KCNQ2 | HRH3 104/4885HTR7 227/4885TSHR 1961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.