Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 6/20 | 0.39 |
| ▸ | METAP2 | P50579 | 2/20 | 0.38 |
| ▸ | MOGAT2 | Q3SYC2 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9898673 | 1.00 | TSHR (0.41) | TSHRHRH3ALDH1A1HTR7METAP2 | |
| Fumaric Acid SCHEMBL9898162 | 0.99 | TSHR (0.41) | TSHRHRH3ALDH1A1HTR7METAP2 | |
| Fumaric Acid SCHEMBL2435682 | 0.99 | TSHR (0.41) | TSHRHRH3ALDH1A1HTR7METAP2 | |
| Fumaric Acid SCHEMBL27987046 | 0.99 | TSHR (0.41) | TSHRHRH3ALDH1A1HTR7METAP2 | |
| Fumaric Acid SCHEMBL2435679 | 0.99 | TSHR (0.41) | TSHRHRH3ALDH1A1HTR7METAP2 | |
| Oxalic Acid SCHEMBL1241171 | 0.95 | HRH3 (0.44) | TSHRHRH3ALDH1A1HTR7METAP2 | |
| SCHEMBL1241268 | 0.93 | HRH3 (0.46) | TSHRHRH3ALDH1A1HTR7MOGAT2 | |
| SCHEMBL2400927 | 0.93 | HRH3 (0.46) | TSHRHRH3ALDH1A1HTR7MOGAT2 | |
| Water SCHEMBL16161850 | 0.93 | HRH3 (0.46) | TSHRHRH3ALDH1A1HTR7MOGAT2 | |
| SCHEMBL5630601 | 0.90 | HTR7 (0.45) | TSHRHRH3ALDH1A1HTR7TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149728-A1 | NOVEL FUMARATE SALTS OF A HISTAMINE H3 RECEPTOR ANTAGONIST | SANOFI (FR) | 2012-06-14 | — | — | US | claimed |
| EP-2445899-B1 | NOVEL FUMARATE SALTS OF A HISTAMINE H3 RECEPTOR ANTAGONIST | SANOFI SA (FR) | 2016-05-11 | — | — | EP | disclosed |
| US-8664245-B2 | Fumarate salts of a histamine H3 receptor antagonist | SANOFI (FR) | 2014-03-04 | — | — | US | disclosed |
| US-20120149728-A1 | NOVEL FUMARATE SALTS OF A HISTAMINE H3 RECEPTOR ANTAGONIST | SANOFI (FR) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149728-A1 | NOVEL FUMARATE SALTS OF A HISTAMINE H3 RECEPTOR ANTAGONIST | HRH4, HRH3, HRH2 | HRH3 2/4885TSHR 716/4885ALDH1A1 3119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.