Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK3 | P27361 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | MAPK10 | P53779 | 7/20 | 0.62 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.62 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.56 |
| ▸ | ULK1 | O75385 | 2/20 | 0.56 |
| ▸ | TYK2 | P29597 | 7/20 | 0.55 |
| ▸ | JAK2 | O60674 | 6/20 | 0.55 |
| ▸ | JAK1 | P23458 | 6/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.51 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12103007 | 0.88 | PTK2 (0.65) | MAPK3MAPK1MAPK10MAPK8MAPK9 | |
| SCHEMBL12103031 | 0.88 | MAPK3 (0.55) | MAPK3MAPK1MAPK10MAPK8MAPK9 | |
| SCHEMBL29777593 | 0.87 | MAPK10 (0.65) | MAPK3MAPK1MAPK10MAPK8MAPK9 | |
| SCHEMBL690590 | 0.87 | MAPK10 (0.65) | MAPK3MAPK1MAPK10MAPK8MAPK9 | |
| SCHEMBL12413721 | 0.85 | TYK2 (0.56) | MAPK3MAPK1MAPK10MAPK9TYK2 | |
| SCHEMBL1232428 | 0.85 | MAPK10 (0.62) | MAPK3MAPK1MAPK10MAPK8MAPK9 | |
| SCHEMBL1559602 | 0.84 | MAPK3 (0.59) | MAPK3MAPK1MAPK10MAPK8MAPK9 | |
| SCHEMBL1559235 | 0.83 | MAPK3 (0.58) | MAPK3MAPK1MAPK10MAPK8MAPK9 | |
| SCHEMBL1559653 | 0.83 | MAPK3 (0.58) | MAPK3MAPK1MAPK10MAPK8MAPK9 | |
| SCHEMBL1559548 | 0.83 | MAPK3 (0.61) | MAPK3MAPK1MAPK10MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8569298-B2 | Pyridine compounds | ASTRAZENECA AB (SE) | 2013-10-29 | — | — | US | disclosed |
| US-20110166139-A1 | PYRIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166139-A1 | PYRIDINE COMPOUNDS | PTK2, PTK2B, PFKP | MAPK3 192/4885MAPK1 149/4885MAPK10 301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.